Toward integrated molecular diagnostic system (i MDx): Principles and applications

Seung Min Park, Andrew F. Sabour, Jun Ho Son, Sang Hun Lee, Luke P. Lee

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Integrated molecular diagnostic systems (iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today.

Original languageEnglish
Article number6775268
Pages (from-to)1506-1521
Number of pages16
JournalIEEE Transactions on Biomedical Engineering
Issue number5
StatePublished - May 2014


  • Diagnostics
  • integration
  • microfluidics
  • point-of-care (POC)


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