TY - JOUR
T1 - Toward integrated molecular diagnostic system (i MDx)
T2 - Principles and applications
AU - Park, Seung Min
AU - Sabour, Andrew F.
AU - Son, Jun Ho
AU - Lee, Sang Hun
AU - Lee, Luke P.
PY - 2014/5
Y1 - 2014/5
N2 - Integrated molecular diagnostic systems (iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today.
AB - Integrated molecular diagnostic systems (iMDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addressed to discuss the practicality for future patient care. We envision that microfluidic systems hold the potential to breakthrough the number of problems brought into the field of medical diagnosis today.
KW - Diagnostics
KW - integration
KW - microfluidics
KW - point-of-care (POC)
UR - http://www.scopus.com/inward/record.url?scp=84899673997&partnerID=8YFLogxK
U2 - 10.1109/TBME.2014.2309119
DO - 10.1109/TBME.2014.2309119
M3 - Article
C2 - 24759281
AN - SCOPUS:84899673997
SN - 0018-9294
VL - 61
SP - 1506
EP - 1521
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 5
M1 - 6775268
ER -