Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step

Yi Xiao, Yangyang Jiang, Chao Xu, Pratanphorn Nakliang, Sanghee Yoon, Sun Choi, Yian Guo, Tao Ye

Research output: Contribution to journalArticlepeer-review

Abstract

The stereocontrolled total synthesis of the antitumor natural product thioamycolamide A has been accomplished in 14 longest linear steps and an overall yield of 19.1%. The central feature of our convergent route to this family of novel macrocyclic natural products is the preparation of the β-alkylthio amide subunit through an auxiliary-controlled, diastereoselective sulfa-Michael addition.

Original languageEnglish
JournalOrganic Chemistry Frontiers
DOIs
StateAccepted/In press - 2022

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