Total synthesis of the L-hexoses

Soo Y. Ko, Albert W.M. Lee, Satoru Masamune, Lawrence A. Reed III, K. Barry Sharpless, Frederick J. Walker

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four key transformations. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

Original languageEnglish
Pages (from-to)245-264
Number of pages20
Issue number1
StatePublished - 1990

Bibliographical note

Funding Information:
ACKNOWLEDGEMENT. We are grateful to the National Institutes of Health (grant GM 31124) and to the National Science Foundation for financial support. High-resolution mass spectra were provided by a facility supported by the National Institutes of Health (grant RR 00317). We are greatly indebted to Drs. Y. Ito, T. Katsuki, P. Ma, V. Martin, D. Tuddenham and S. Viti for their contributions which provided the foundation for the present work.


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