Total synthesis of the L-hexoses

Soo Y. Ko, Albert W.M. Lee, Satoru Masamune, Lawrence A. Reed, K. Barry Sharpless, Frederick J. Walker

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

Original languageEnglish
Pages (from-to)949-951
Number of pages3
JournalScience
Volume220
Issue number4600
DOIs
StatePublished - 1983

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