Total synthesis of the L-hexoses

Soo Y. Ko; Albert W.M. Lee; Satoru Masamune; Lawrence A. Reed; K. Barry Sharpless; Frederick J. Walker

doi:10.1126/science.220.4600.949

Total synthesis of the L-hexoses

Soo Y. Ko, Albert W.M. Lee, Satoru Masamune, Lawrence A. Reed, K. Barry Sharpless, Frederick J. Walker

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

Original language	English
Pages (from-to)	949-951
Number of pages	3
Journal	Science
Volume	220
Issue number	4600
DOIs	https://doi.org/10.1126/science.220.4600.949
State	Published - 1983

Bibliographical note

Funding Information:
ACKNOWLEDGEMENT. We are grateful to the National Institutes of Health (grant GM 31124) and to the National Science Foundation for financial support. High-resolution mass spectra were provided by a facility supported by the National Institutes of Health (grant RR 00317). We are greatly indebted to Drs. Y. Ito, T. Katsuki, P. Ma, V. Martin, D. Tuddenham and S. Viti for their contributions which provided the foundation for the present work.

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title = "Total synthesis of the L-hexoses",

abstract = "Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.",

author = "Ko, {Soo Y.} and Lee, {Albert W.M.} and Satoru Masamune and Reed, {Lawrence A.} and {Barry Sharpless}, K. and Walker, {Frederick J.}",

note = "Funding Information: ACKNOWLEDGEMENT. We are grateful to the National Institutes of Health (grant GM 31124) and to the National Science Foundation for financial support. High-resolution mass spectra were provided by a facility supported by the National Institutes of Health (grant RR 00317). We are greatly indebted to Drs. Y. Ito, T. Katsuki, P. Ma, V. Martin, D. Tuddenham and S. Viti for their contributions which provided the foundation for the present work.",

year = "1983",

doi = "10.1126/science.220.4600.949",

language = "English",

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T1 - Total synthesis of the L-hexoses

AU - Ko, Soo Y.

AU - Lee, Albert W.M.

AU - Masamune, Satoru

AU - Reed, Lawrence A.

AU - Barry Sharpless, K.

AU - Walker, Frederick J.

N1 - Funding Information: ACKNOWLEDGEMENT. We are grateful to the National Institutes of Health (grant GM 31124) and to the National Science Foundation for financial support. High-resolution mass spectra were provided by a facility supported by the National Institutes of Health (grant RR 00317). We are greatly indebted to Drs. Y. Ito, T. Katsuki, P. Ma, V. Martin, D. Tuddenham and S. Viti for their contributions which provided the foundation for the present work.

PY - 1983

Y1 - 1983

N2 - Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

AB - Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

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U2 - 10.1126/science.220.4600.949

DO - 10.1126/science.220.4600.949

M3 - Article

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AN - SCOPUS:0020645466

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VL - 220

SP - 949

EP - 951

JO - Science

JF - Science

IS - 4600

ER -

Total synthesis of the L-hexoses

Abstract

Bibliographical note

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