Abstract
Sufentanil, a potent anilidopiperidine analgesic, was synthesized from a simple thiophenylethylamine via six step sequence. The key parts of this synthesis involved an efficient construction of thiophenylethylpiperidone by aminomethano desilylation-cyclization followed by Swern oxidation and a direct regioselective N-nucleophilic spiral epoxide cleavage with aniline promoted by Lewis acids.
Original language | English |
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Pages (from-to) | 398-400 |
Number of pages | 3 |
Journal | Archives of Pharmacal Research |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1999 |
Keywords
- Analgesics
- Oxirane
- Piperidine
- Sufentanil
- Total Synthesis