Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction as a Key Step

Yian Guo, Jingjing Zhou, Bowen Gao, Meng Zhao, Jia Lei Yan, Zhengshuang Xu, Sun Choi, Tao Ye

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The first total synthesis of neurotoxic cyclodepsipeptide hoiamide A (1) has been accomplished. The synthesis features the use of an Evans-Tishchenko fragment coupling between a five-stereogenic-center-containing β-hydroxyketone and a chiral aldehyde derived from threonine.

Original languageEnglish
Pages (from-to)5471-5474
Number of pages4
JournalOrganic Letters
Volume21
Issue number14
DOIs
StatePublished - 5 Jul 2019

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