Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus

Ah Reum Han; Hyen Joo Park; Daofeng Chen; Dae Sik Jang; Hwa Jung Kim; Sang Kook Lee; Eun Kyoung Seo

doi:10.1002/cbdv.200790127

Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus

Ah Reum Han
, Hyen Joo Park
, Daofeng Chen
, Dae Sik Jang
, Hwa Jung Kim
, Sang Kook Lee
, Eun Kyoung Seo

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC₅₀ values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp.

Original language	English
Pages (from-to)	1487-1491
Number of pages	5
Journal	Chemistry and Biodiversity
Volume	4
Issue number	7
DOIs	https://doi.org/10.1002/cbdv.200790127
State	Published - 2007

Access to Document

10.1002/cbdv.200790127

Cite this

@article{f697c1f234c540949aef4d954db8540d,

title = "Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus",

abstract = "Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp.",

author = "Han, \{Ah Reum\} and Park, \{Hyen Joo\} and Daofeng Chen and Jang, \{Dae Sik\} and Kim, \{Hwa Jung\} and Lee, \{Sang Kook\} and Seo, \{Eun Kyoung\}",

year = "2007",

doi = "10.1002/cbdv.200790127",

language = "English",

volume = "4",

pages = "1487--1491",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-Blackwell",

number = "7",

}

TY - JOUR

T1 - Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus

AU - Han, Ah Reum

AU - Park, Hyen Joo

AU - Chen, Daofeng

AU - Jang, Dae Sik

AU - Kim, Hwa Jung

AU - Lee, Sang Kook

AU - Seo, Eun Kyoung

PY - 2007

Y1 - 2007

N2 - Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp.

AB - Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp.

UR - https://www.scopus.com/pages/publications/34547520341

U2 - 10.1002/cbdv.200790127

DO - 10.1002/cbdv.200790127

M3 - Article

C2 - 17638329

AN - SCOPUS:34547520341

SN - 1612-1872

VL - 4

SP - 1487

EP - 1491

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 7

ER -

Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus

Abstract

Access to Document

Fingerprint

Cite this