Topoisomerase-II-Inhibitory principles from the stems of Spatholobus suberectus

Ah Reum Han, Hyen Joo Park, Daofeng Chen, Dae Sik Jang, Hwa Jung Kim, Sang Kook Lee, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp.

Original languageEnglish
Pages (from-to)1487-1491
Number of pages5
JournalChemistry and Biodiversity
Volume4
Issue number7
DOIs
StatePublished - 2007

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