Abstract
Bioassay-guided fractionation of the stems of Spatholobus suberectus led to the isolation of procyanidin B4 (=(+)-catechin-(4→8)-(-)-epicatechin) (1) and (+)-catechin-(4→8)-(+)-catechin(4→8)-(-)-epicatechin (2). These compounds, isolated before from other sources, were found to be highly potent inhibitors of DNA-topoisomerase-II (Topo-II)-mediated KDNA decatenation, with IC50 values of 22.5 ± 2.3 and 21.9 ±2.2 nM, resp.
Original language | English |
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Pages (from-to) | 1487-1491 |
Number of pages | 5 |
Journal | Chemistry and Biodiversity |
Volume | 4 |
Issue number | 7 |
DOIs | |
State | Published - 2007 |