Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.
Bibliographical noteFunding Information:
Supported by the Korea Health Technology RD Project through the Korea Health Industry Development Institute; the Ministry of Health and Welfare, No. HI16C-2207; the Basic Science Research Program through the NRF, No. NRF- 2018R1D1A1A09083264; Ewha Womans University, No. RP-grant 2017.
© The Author(s) 2019.
- Cell therapy
- Stem cell
- Tonsil-derived stem cell