Thymosin beta 4 induces hair growth via stem cell migration and differentiation

Deborah Philp, Sharleen St-Surin, Hee Jae Cha, Hye Sung Moon, Hynda K. Kleinman, Michael Elkin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

46 Scopus citations

Abstract

Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
PublisherBlackwell Publishing Inc.
Pages95-103
Number of pages9
ISBN (Print)1573317012, 9781573317016
DOIs
StatePublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1112
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Angiogenesis
  • Cell migration
  • Cell survival
  • Endothelial cells
  • Gene expression
  • Hair follicle growth
  • Inflammation
  • Keratinocytes
  • Laminin-5
  • MMPs
  • Proteases
  • Stem cells
  • Thymosin beta 4
  • TIMPs
  • Wound healing
  • Zyxin

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