Three-month treatment response and exacerbation in chronic obstructive pulmonary disease

Jung Su Lee; Chin Kook Rhee; Kwang Ha Yoo; Ji Hyun Lee; Ho Il Yoon; Tae Hyung Kim; Woo Jin Kim; Jin Hwa Lee; Seong Yong Lim; Tai Sun Park; Jae Seung Lee; Sei Won Lee; Sang Do Lee; Yeon Mok Oh

doi:10.3346/jkms.2015.30.1.54

Three-month treatment response and exacerbation in chronic obstructive pulmonary disease

Jung Su Lee
, Chin Kook Rhee
, Kwang Ha Yoo
, Ji Hyun Lee
, Ho Il Yoon
, Tae Hyung Kim
, Woo Jin Kim
, Jin Hwa Lee
, Seong Yong Lim
, Tai Sun Park
, Jae Seung Lee
, Sei Won Lee
, Sang Do Lee
, Yeon Mok Oh

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The aim of this study was to investigate relationships between acute exacerbation andForced Expiratory Volume 1 second (FEV1) improvement after treatment with combinedlong-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronicobstructive pulmonary disease (COPD). A total of 137 COPD patients were classified asresponders or nonresponders according to FEV1 improvement after 3 months of LABA/ICStreatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these twosubgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%)were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbationsoccurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in thenonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was asignificant prognostic factor for fewer acute exacerbations in a multivariate Coxproportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walkdistance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for theoccurrence of acute exacerbation in COPD patients.

Original language	English
Pages (from-to)	54-59
Number of pages	6
Journal	Journal of Korean Medical Science
Volume	30
Issue number	1
DOIs	https://doi.org/10.3346/jkms.2015.30.1.54
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015 The Korean Academy of Medical Sciences.

Keywords

Disease progression
Forced expiratory volume
Pulmonary disease, chronic obstructive

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10.3346/jkms.2015.30.1.54

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title = "Three-month treatment response and exacerbation in chronic obstructive pulmonary disease",

abstract = "The aim of this study was to investigate relationships between acute exacerbation andForced Expiratory Volume 1 second (FEV1) improvement after treatment with combinedlong-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronicobstructive pulmonary disease (COPD). A total of 137 COPD patients were classified asresponders or nonresponders according to FEV1 improvement after 3 months of LABA/ICStreatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these twosubgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4\%)were classified as responders and 57 (41.6\%) as nonresponders. Acute exacerbationsoccurred in 25 patients (31.3\%) in the responder group and in 26 patients (45.6\%) in thenonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was asignificant prognostic factor for fewer acute exacerbations in a multivariate Coxproportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walkdistance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for theoccurrence of acute exacerbation in COPD patients.",

keywords = "Disease progression, Forced expiratory volume, Pulmonary disease, chronic obstructive",

author = "Lee, \{Jung Su\} and Rhee, \{Chin Kook\} and Yoo, \{Kwang Ha\} and Lee, \{Ji Hyun\} and Yoon, \{Ho Il\} and Kim, \{Tae Hyung\} and Kim, \{Woo Jin\} and Lee, \{Jin Hwa\} and Lim, \{Seong Yong\} and Park, \{Tai Sun\} and Lee, \{Jae Seung\} and Lee, \{Sei Won\} and Lee, \{Sang Do\} and Oh, \{Yeon Mok\}",

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doi = "10.3346/jkms.2015.30.1.54",

language = "English",

volume = "30",

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T1 - Three-month treatment response and exacerbation in chronic obstructive pulmonary disease

AU - Lee, Jung Su

AU - Rhee, Chin Kook

AU - Yoo, Kwang Ha

AU - Lee, Ji Hyun

AU - Yoon, Ho Il

AU - Kim, Tae Hyung

AU - Kim, Woo Jin

AU - Lee, Jin Hwa

AU - Lim, Seong Yong

AU - Park, Tai Sun

AU - Lee, Jae Seung

AU - Lee, Sei Won

AU - Lee, Sang Do

AU - Oh, Yeon Mok

PY - 2015

Y1 - 2015

N2 - The aim of this study was to investigate relationships between acute exacerbation andForced Expiratory Volume 1 second (FEV1) improvement after treatment with combinedlong-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronicobstructive pulmonary disease (COPD). A total of 137 COPD patients were classified asresponders or nonresponders according to FEV1 improvement after 3 months of LABA/ICStreatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these twosubgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%)were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbationsoccurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in thenonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was asignificant prognostic factor for fewer acute exacerbations in a multivariate Coxproportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walkdistance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for theoccurrence of acute exacerbation in COPD patients.

AB - The aim of this study was to investigate relationships between acute exacerbation andForced Expiratory Volume 1 second (FEV1) improvement after treatment with combinedlong-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronicobstructive pulmonary disease (COPD). A total of 137 COPD patients were classified asresponders or nonresponders according to FEV1 improvement after 3 months of LABA/ICStreatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these twosubgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%)were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbationsoccurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in thenonresponder group (P = 0.086). FEV1 improvement after LABA/ICS treatment was asignificant prognostic factor for fewer acute exacerbations in a multivariate Coxproportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walkdistance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for theoccurrence of acute exacerbation in COPD patients.

KW - Disease progression

KW - Forced expiratory volume

KW - Pulmonary disease, chronic obstructive

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SN - 1011-8934

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SP - 54

EP - 59

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 1

ER -

Three-month treatment response and exacerbation in chronic obstructive pulmonary disease

Abstract

Bibliographical note

Keywords

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