Thermosensitive PEGylated polypeptides

Jang Young Cho; Youn Soo Sohn; Anna Gutowska; Byeongmoon Jeong

doi:10.1002/marc.200300318

Thermosensitive PEGylated polypeptides

Jang Young Cho
, Youn Soo Sohn
, Anna Gutowska
, Byeongmoon Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40°C by varying the number of poly(ethylene glycol) grafts. This system might he promising for advanced drug delivery.

Original language	English
Pages (from-to)	964-967
Number of pages	4
Journal	Macromolecular Rapid Communications
Volume	25
Issue number	9
DOIs	https://doi.org/10.1002/marc.200300318
State	Published - 7 May 2004

Keywords

Biodegradable
Drug delivery systems
Nanoparticles
Peptides
Thermal properties

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10.1002/marc.200300318

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title = "Thermosensitive PEGylated polypeptides",

abstract = "We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40°C by varying the number of poly(ethylene glycol) grafts. This system might he promising for advanced drug delivery.",

keywords = "Biodegradable, Drug delivery systems, Nanoparticles, Peptides, Thermal properties",

author = "Cho, \{Jang Young\} and Sohn, \{Youn Soo\} and Anna Gutowska and Byeongmoon Jeong",

year = "2004",

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AU - Cho, Jang Young

AU - Sohn, Youn Soo

AU - Gutowska, Anna

AU - Jeong, Byeongmoon

PY - 2004/5/7

Y1 - 2004/5/7

N2 - We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40°C by varying the number of poly(ethylene glycol) grafts. This system might he promising for advanced drug delivery.

AB - We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40°C by varying the number of poly(ethylene glycol) grafts. This system might he promising for advanced drug delivery.

KW - Biodegradable

KW - Drug delivery systems

KW - Nanoparticles

KW - Peptides

KW - Thermal properties

UR - https://www.scopus.com/pages/publications/4544352785

U2 - 10.1002/marc.200300318

DO - 10.1002/marc.200300318

M3 - Article

AN - SCOPUS:4544352785

SN - 1022-1336

VL - 25

SP - 964

EP - 967

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 9

ER -

Thermosensitive PEGylated polypeptides

Abstract

Keywords

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