Abstract
We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40°C by varying the number of poly(ethylene glycol) grafts. This system might he promising for advanced drug delivery.
Original language | English |
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Pages (from-to) | 964-967 |
Number of pages | 4 |
Journal | Macromolecular Rapid Communications |
Volume | 25 |
Issue number | 9 |
DOIs | |
State | Published - 7 May 2004 |
Keywords
- Biodegradable
- Drug delivery systems
- Nanoparticles
- Peptides
- Thermal properties