Thermosensitive PEGylated polypeptides

Jang Young Cho, Youn Soo Sohn, Anna Gutowska, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


We report a thermosensitive polypeptide consisting of hydrophilic poly(ethylene glycol)s and hydrophobic phenyl alanine ethyl esters. It is soluble in most solvents and undergoes a micelle (radius ≈ 10 nm) to nanoparticle (radius ≈ 100 nm) transition in water as the temperature increases. The transition temperature could be controlled to between 30 and 40°C by varying the number of poly(ethylene glycol) grafts. This system might he promising for advanced drug delivery.

Original languageEnglish
Pages (from-to)964-967
Number of pages4
JournalMacromolecular Rapid Communications
Issue number9
StatePublished - 7 May 2004


  • Biodegradable
  • Drug delivery systems
  • Nanoparticles
  • Peptides
  • Thermal properties


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