Thermosensitive micelles from PEGylated oligopeptides

Jing Zhe Xu; Sun Hee Moon; Byeongmoon Jeong; Youn Soo Sohn

doi:10.1016/j.polymer.2007.04.061

Thermosensitive micelles from PEGylated oligopeptides

Jing Zhe Xu, Sun Hee Moon, Byeongmoon Jeong, Youn Soo Sohn

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

New thermosensitive and micelle-forming diblock copolymers were synthesized by amide coupling of carboxylated methoxy-poly(ethylene glycols) with hydrophobic oligopeptides and characterized by means of ¹H NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) measurements. Stable micelles were formed from copolymers composed of MPEG550 or MPEG750 as a hydrophilic segment and the hexapeptide, GlyPheLeuGlyPheLeuEt, as a hydrophobic segment. All the present diblock copolymers exhibited thermosensitive properties by showing a lower critical solution temperature (LCST) in water. The LCST of the copolymers composed of relatively shorter MPEG350 and GlyPheLeuAspEt₂ was observed at much higher temperature (48 °C) compared with the LCST (29 °C) of the cyclotriphosphazene analogues bearing the same hydrophilic and hydrophobic segments as side groups. The remarkably lower LCST of the cyclotriphosphazene analogue is presumed to be due to the structural effect of the cis-nongeminal conformation of its three hydrophobic oligopeptides, but such a structural effect was found to diminish as the chain lengths of the hydrophilic and hydrophobic blocks of the copolymers increased.

Original language	English
Pages (from-to)	3673-3678
Number of pages	6
Journal	Polymer
Volume	48
Issue number	13
DOIs	https://doi.org/10.1016/j.polymer.2007.04.061
State	Published - 15 Jun 2007

Bibliographical note

Funding Information:
This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0), by a Korean Research Foundation Grant (KRF-2004-005-C00090), and Ministry of Commerce, Industry and Energy of Korea.

Keywords

Oligopeptide
Poly(ethylene glycol)
Thermosensitive micelle

Access to Document

10.1016/j.polymer.2007.04.061

Cite this

@article{c4926d1e575c4d4eb6c1ae62e58013df,

title = "Thermosensitive micelles from PEGylated oligopeptides",

abstract = "New thermosensitive and micelle-forming diblock copolymers were synthesized by amide coupling of carboxylated methoxy-poly(ethylene glycols) with hydrophobic oligopeptides and characterized by means of 1H NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) measurements. Stable micelles were formed from copolymers composed of MPEG550 or MPEG750 as a hydrophilic segment and the hexapeptide, GlyPheLeuGlyPheLeuEt, as a hydrophobic segment. All the present diblock copolymers exhibited thermosensitive properties by showing a lower critical solution temperature (LCST) in water. The LCST of the copolymers composed of relatively shorter MPEG350 and GlyPheLeuAspEt2 was observed at much higher temperature (48 °C) compared with the LCST (29 °C) of the cyclotriphosphazene analogues bearing the same hydrophilic and hydrophobic segments as side groups. The remarkably lower LCST of the cyclotriphosphazene analogue is presumed to be due to the structural effect of the cis-nongeminal conformation of its three hydrophobic oligopeptides, but such a structural effect was found to diminish as the chain lengths of the hydrophilic and hydrophobic blocks of the copolymers increased.",

keywords = "Oligopeptide, Poly(ethylene glycol), Thermosensitive micelle",

author = "Xu, {Jing Zhe} and Moon, {Sun Hee} and Byeongmoon Jeong and Sohn, {Youn Soo}",

note = "Funding Information: This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0), by a Korean Research Foundation Grant (KRF-2004-005-C00090), and Ministry of Commerce, Industry and Energy of Korea.",

year = "2007",

month = jun,

day = "15",

doi = "10.1016/j.polymer.2007.04.061",

language = "English",

volume = "48",

pages = "3673--3678",

journal = "Polymer",

issn = "0032-3861",

publisher = "Elsevier BV",

number = "13",

}

TY - JOUR

T1 - Thermosensitive micelles from PEGylated oligopeptides

AU - Xu, Jing Zhe

AU - Moon, Sun Hee

AU - Jeong, Byeongmoon

AU - Sohn, Youn Soo

N1 - Funding Information: This work was supported by the SRC program of the Korea Science and Engineering Foundation through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (Grant R11-2005-008-01002-0), by a Korean Research Foundation Grant (KRF-2004-005-C00090), and Ministry of Commerce, Industry and Energy of Korea.

PY - 2007/6/15

Y1 - 2007/6/15

N2 - New thermosensitive and micelle-forming diblock copolymers were synthesized by amide coupling of carboxylated methoxy-poly(ethylene glycols) with hydrophobic oligopeptides and characterized by means of 1H NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) measurements. Stable micelles were formed from copolymers composed of MPEG550 or MPEG750 as a hydrophilic segment and the hexapeptide, GlyPheLeuGlyPheLeuEt, as a hydrophobic segment. All the present diblock copolymers exhibited thermosensitive properties by showing a lower critical solution temperature (LCST) in water. The LCST of the copolymers composed of relatively shorter MPEG350 and GlyPheLeuAspEt2 was observed at much higher temperature (48 °C) compared with the LCST (29 °C) of the cyclotriphosphazene analogues bearing the same hydrophilic and hydrophobic segments as side groups. The remarkably lower LCST of the cyclotriphosphazene analogue is presumed to be due to the structural effect of the cis-nongeminal conformation of its three hydrophobic oligopeptides, but such a structural effect was found to diminish as the chain lengths of the hydrophilic and hydrophobic blocks of the copolymers increased.

AB - New thermosensitive and micelle-forming diblock copolymers were synthesized by amide coupling of carboxylated methoxy-poly(ethylene glycols) with hydrophobic oligopeptides and characterized by means of 1H NMR spectroscopy, elemental analysis, and dynamic light scattering (DLS) measurements. Stable micelles were formed from copolymers composed of MPEG550 or MPEG750 as a hydrophilic segment and the hexapeptide, GlyPheLeuGlyPheLeuEt, as a hydrophobic segment. All the present diblock copolymers exhibited thermosensitive properties by showing a lower critical solution temperature (LCST) in water. The LCST of the copolymers composed of relatively shorter MPEG350 and GlyPheLeuAspEt2 was observed at much higher temperature (48 °C) compared with the LCST (29 °C) of the cyclotriphosphazene analogues bearing the same hydrophilic and hydrophobic segments as side groups. The remarkably lower LCST of the cyclotriphosphazene analogue is presumed to be due to the structural effect of the cis-nongeminal conformation of its three hydrophobic oligopeptides, but such a structural effect was found to diminish as the chain lengths of the hydrophilic and hydrophobic blocks of the copolymers increased.

KW - Oligopeptide

KW - Poly(ethylene glycol)

KW - Thermosensitive micelle

UR - http://www.scopus.com/inward/record.url?scp=34249805733&partnerID=8YFLogxK

U2 - 10.1016/j.polymer.2007.04.061

DO - 10.1016/j.polymer.2007.04.061

M3 - Article

AN - SCOPUS:34249805733

SN - 0032-3861

VL - 48

SP - 3673

EP - 3678

JO - Polymer

JF - Polymer

IS - 13

ER -

Thermosensitive micelles from PEGylated oligopeptides

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this