Thermosensitive chitosan as an injectable carrier for local drug delivery

Jin Woo Bae, Dong Hyun Go, Ki Dong Park, Seung Jin Lee

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Two types of injectable system using thermosensitive chitosan (chitosan-g-NIPAAm), hydrogel and microparticles (MPs)-embedded hydrogel were developed as drug carriers for controlled release and their pharmaceutical potentials were investigated. 5-Fluorouracil (5-FU)-loaded, biodegradable PLGA MPs were prepared by a double emulsion method and then simply mixed with an aqueous solution of thermosensitive chitosan at room temperature. All 5-FU release rates from the hydrogel matrix were faster than bovine serum albumin (BSA), possibly due to the difference in the molecular weight of the drugs. The 5-FU release profile from MPs-embedded hydrogel was shown to reduce the burst effect and exhibit nearly zero-order release behavior from the beginning of each initial stage. Thus, these MPs-embedded hydrogels, as well as thermosensitive chitosan hydrogel, have promising potential as an injectable drug carrier for pharmaceutical applications.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalMacromolecular Research
Volume14
Issue number4
DOIs
StatePublished - Aug 2006

Keywords

  • Chitosan
  • Drug delivery
  • Injectable
  • Microparticle
  • Thermosensitive hydrogel

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