Thermogelling poly(caprolactone-6-ethylene glycol-b-caprolactone) aqueous solutions

Soo Jin Bae; Ju Myung Suh; Youn Soo Sohn; You Han Bae; Sung Wan Kim; Byeongmoon Jeong

doi:10.1021/ma050489m

Thermogelling poly(caprolactone-6-ethylene glycol-b-caprolactone) aqueous solutions

Soo Jin Bae, Ju Myung Suh, Youn Soo Sohn, You Han Bae, Sung Wan Kim, Byeongmoon Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

271 Scopus citations

Abstract

Poly(caprolactone-b-ethylene glycol-b-caprolactone) (PCL-PEG-PCL) triblock copolymer aqueous solution (> 15 wt %) undergoes the sol-gel-sol transition as the temperature increases from 10 to 60°C. The mechanism and structure-property relationship of the sol-gel transition were investigated. In particular, compared with the PEG-PCL-PEG triblock copolymers recently reported by our group, PCL-PEG-PCL has (1) a synthetic advantage without a hexamethylene diisocyanate coupling step, (2) a wider gel window of over 15-32 wt %, and (3) a larger gel modulus. Both PEG-PCL-PEG and PCL-PEG-PCL polymers are an important progress in the biodegradable thermogelling system in that they can be lyophilized in a powder form, are easy to handle, are easy to redissolve to a clear solution, and show little syneresis through the gel phase.

Original language	English
Pages (from-to)	5260-5265
Number of pages	6
Journal	Macromolecules
Volume	38
Issue number	12
DOIs	https://doi.org/10.1021/ma050489m
State	Published - 14 Jun 2005

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title = "Thermogelling poly(caprolactone-6-ethylene glycol-b-caprolactone) aqueous solutions",

abstract = "Poly(caprolactone-b-ethylene glycol-b-caprolactone) (PCL-PEG-PCL) triblock copolymer aqueous solution (> 15 wt %) undergoes the sol-gel-sol transition as the temperature increases from 10 to 60°C. The mechanism and structure-property relationship of the sol-gel transition were investigated. In particular, compared with the PEG-PCL-PEG triblock copolymers recently reported by our group, PCL-PEG-PCL has (1) a synthetic advantage without a hexamethylene diisocyanate coupling step, (2) a wider gel window of over 15-32 wt %, and (3) a larger gel modulus. Both PEG-PCL-PEG and PCL-PEG-PCL polymers are an important progress in the biodegradable thermogelling system in that they can be lyophilized in a powder form, are easy to handle, are easy to redissolve to a clear solution, and show little syneresis through the gel phase.",

author = "Bae, {Soo Jin} and Suh, {Ju Myung} and Sohn, {Youn Soo} and Bae, {You Han} and Kim, {Sung Wan} and Byeongmoon Jeong",

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T1 - Thermogelling poly(caprolactone-6-ethylene glycol-b-caprolactone) aqueous solutions

AU - Bae, Soo Jin

AU - Suh, Ju Myung

AU - Sohn, Youn Soo

AU - Bae, You Han

AU - Kim, Sung Wan

AU - Jeong, Byeongmoon

PY - 2005/6/14

Y1 - 2005/6/14

N2 - Poly(caprolactone-b-ethylene glycol-b-caprolactone) (PCL-PEG-PCL) triblock copolymer aqueous solution (> 15 wt %) undergoes the sol-gel-sol transition as the temperature increases from 10 to 60°C. The mechanism and structure-property relationship of the sol-gel transition were investigated. In particular, compared with the PEG-PCL-PEG triblock copolymers recently reported by our group, PCL-PEG-PCL has (1) a synthetic advantage without a hexamethylene diisocyanate coupling step, (2) a wider gel window of over 15-32 wt %, and (3) a larger gel modulus. Both PEG-PCL-PEG and PCL-PEG-PCL polymers are an important progress in the biodegradable thermogelling system in that they can be lyophilized in a powder form, are easy to handle, are easy to redissolve to a clear solution, and show little syneresis through the gel phase.

AB - Poly(caprolactone-b-ethylene glycol-b-caprolactone) (PCL-PEG-PCL) triblock copolymer aqueous solution (> 15 wt %) undergoes the sol-gel-sol transition as the temperature increases from 10 to 60°C. The mechanism and structure-property relationship of the sol-gel transition were investigated. In particular, compared with the PEG-PCL-PEG triblock copolymers recently reported by our group, PCL-PEG-PCL has (1) a synthetic advantage without a hexamethylene diisocyanate coupling step, (2) a wider gel window of over 15-32 wt %, and (3) a larger gel modulus. Both PEG-PCL-PEG and PCL-PEG-PCL polymers are an important progress in the biodegradable thermogelling system in that they can be lyophilized in a powder form, are easy to handle, are easy to redissolve to a clear solution, and show little syneresis through the gel phase.

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Thermogelling poly(caprolactone-6-ethylene glycol-b-caprolactone) aqueous solutions

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