Thermogelling biodegradable polymers with hydrophilic backbones: PEG-g-PLGA

Byeongmoon Jeong, Merinda R. Kibbey, Jerome C. Birnbaum, You Yeon Won, Anna Gutowska

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

The aqueous solutions of poly(ethylene glycol) grafted with poly(lactic acid-co-glycolic acid) flow freely at room temperature but form gels at higher temperature. The existence of micelles in water at low polymer concentration was confirmed by cryo-transmission electron microscopy and dye solubilization studies. The micellar diameter is about 9 nm, and the critical micelle concentration is in a range of 0.01-0.05 wt%. The critical gel concentration, above which a gel phase appears, was 16 wt%, and the sol-to-gel transition temperature was slightly affected by the concentration between 16 and 25 wt%. At sol-to-gel transition, viscosity and modulus increased abruptly, and 13C NMR showed molecular motion of hydrophilic poly(ethylene glycol) backbones decreased while that of hydrophobic poly(lactic acid-co-glycolic acid) side chains increased. The hydrogel of PEG-g-PLGA with hydrophilic backbones was transparent during degradation and remained a gel for 1 week, suggesting a promising material for short-term drug delivery.

Original languageEnglish
Pages (from-to)8317-8322
Number of pages6
JournalMacromolecules
Volume33
Issue number22
DOIs
StatePublished - 31 Oct 2000

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