Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering

Byeongmoon Jeong; Kyeonghee M. Lee; Anna Gutowska; Yuehuei H. An

doi:10.1021/bm025536m

Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering

Byeongmoon Jeong, Kyeonghee M. Lee, Anna Gutowska, Yuehuei H. An

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers insulin formulation, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. The cartilage defect was notably repaired using chondrocyte suspension in the thermogelling PLGA-g-PEG compared with a control. This report shows that thermogelling biodegradable PLGA/PEG graft copolymer system can be a promising platform for protein and cell-based therapy.

Original language	English
Pages (from-to)	865-868
Number of pages	4
Journal	Biomacromolecules
Volume	3
Issue number	4
DOIs	https://doi.org/10.1021/bm025536m
State	Published - 2002

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abstract = "This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers insulin formulation, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. The cartilage defect was notably repaired using chondrocyte suspension in the thermogelling PLGA-g-PEG compared with a control. This report shows that thermogelling biodegradable PLGA/PEG graft copolymer system can be a promising platform for protein and cell-based therapy.",

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PY - 2002

Y1 - 2002

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AB - This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers insulin formulation, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. The cartilage defect was notably repaired using chondrocyte suspension in the thermogelling PLGA-g-PEG compared with a control. This report shows that thermogelling biodegradable PLGA/PEG graft copolymer system can be a promising platform for protein and cell-based therapy.

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Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering

Abstract

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