Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering

Byeongmoon Jeong, Kyeonghee M. Lee, Anna Gutowska, Yuehuei H. An

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers insulin formulation, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. The cartilage defect was notably repaired using chondrocyte suspension in the thermogelling PLGA-g-PEG compared with a control. This report shows that thermogelling biodegradable PLGA/PEG graft copolymer system can be a promising platform for protein and cell-based therapy.

Original languageEnglish
Pages (from-to)865-868
Number of pages4
JournalBiomacromolecules
Volume3
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Dive into the research topics of 'Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering'. Together they form a unique fingerprint.

Cite this