Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

Tae Jin Song, Byung Su Kim, Min Kyung Chu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations


Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.

Original languageEnglish
Title of host publicationProgress in Brain Research
EditorsShuu-Jiun Wang, Shuu-Jiun Wang, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau
PublisherElsevier B.V.
Number of pages27
ISBN (Print)9780128211083
StatePublished - 2020

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Bibliographical note

Funding Information:
TJS and BSK declare that there are no conflicts of interest regarding this submission. MKC is a site investigator for a multi-center trial sponsored by Otsuka Korea, Novartis International AG, and Eli Lilly and Company. He has served as an advisory member for Teva and received lecture honoraria from Allergan Korea, Handok-Teva, and Yuyu Pharmaceutical Company in the past 24 months. He received grants from Yonsei University College of Medicine (2018-32-0037) and National Research Foundation of Korea (2019R1F1A1053841).

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019R1F1A1053841).

Publisher Copyright:
© 2020 Elsevier B.V.


  • Circadian rhythm
  • Circadian rhythm sleep disorders
  • Headache
  • Insomnia
  • Melatonin
  • Migraine


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