Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

Tae Jin Song, Byung Su Kim, Min Kyung Chu

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.

Original languageEnglish
Title of host publicationProgress in Brain Research
EditorsShuu-Jiun Wang, Shuu-Jiun Wang, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau
PublisherElsevier B.V.
Pages343-369
Number of pages27
ISBN (Print)9780128211083
DOIs
StatePublished - 2020

Publication series

NameProgress in Brain Research
Volume255
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Circadian rhythm
  • Circadian rhythm sleep disorders
  • Headache
  • Insomnia
  • Melatonin
  • Migraine

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