Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

Tae Jin Song; Byung Su Kim; Min Kyung Chu

doi:10.1016/bs.pbr.2020.05.014

Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

Tae Jin Song, Byung Su Kim, Min Kyung Chu

Department of Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

11 Scopus citations

Abstract

Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.

Original language	English
Title of host publication	Progress in Brain Research
Editors	Shuu-Jiun Wang, Shuu-Jiun Wang, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau, Chi Ieong Lau
Publisher	Elsevier B.V.
Pages	343-369
Number of pages	27
ISBN (Print)	9780128211083
DOIs	https://doi.org/10.1016/bs.pbr.2020.05.014
State	Published - 2020

Publication series

Name	Progress in Brain Research
Volume	255
ISSN (Print)	0079-6123
ISSN (Electronic)	1875-7855

Bibliographical note

Funding Information:
TJS and BSK declare that there are no conflicts of interest regarding this submission. MKC is a site investigator for a multi-center trial sponsored by Otsuka Korea, Novartis International AG, and Eli Lilly and Company. He has served as an advisory member for Teva and received lecture honoraria from Allergan Korea, Handok-Teva, and Yuyu Pharmaceutical Company in the past 24 months. He received grants from Yonsei University College of Medicine (2018-32-0037) and National Research Foundation of Korea (2019R1F1A1053841).

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019R1F1A1053841).

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

Circadian rhythm
Circadian rhythm sleep disorders
Headache
Insomnia
Melatonin
Migraine

Access to Document

10.1016/bs.pbr.2020.05.014

Cite this

Song, T. J., Kim, B. S., & Chu, M. K. (2020). Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine? In S.-J. Wang, S.-J. Wang, C. I. Lau, C. I. Lau, C. I. Lau, C. I. Lau, & C. I. Lau (Eds.), Progress in Brain Research (pp. 343-369). (Progress in Brain Research; Vol. 255). Elsevier B.V.. https://doi.org/10.1016/bs.pbr.2020.05.014

@inbook{bbd5272938b34fd7a00de93a9bdcc0e3,

title = "Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?",

abstract = "Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.",

keywords = "Circadian rhythm, Circadian rhythm sleep disorders, Headache, Insomnia, Melatonin, Migraine",

author = "Song, {Tae Jin} and Kim, {Byung Su} and Chu, {Min Kyung}",

note = "Funding Information: TJS and BSK declare that there are no conflicts of interest regarding this submission. MKC is a site investigator for a multi-center trial sponsored by Otsuka Korea, Novartis International AG, and Eli Lilly and Company. He has served as an advisory member for Teva and received lecture honoraria from Allergan Korea, Handok-Teva, and Yuyu Pharmaceutical Company in the past 24 months. He received grants from Yonsei University College of Medicine (2018-32-0037) and National Research Foundation of Korea (2019R1F1A1053841). Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019R1F1A1053841). Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

doi = "10.1016/bs.pbr.2020.05.014",

language = "English",

isbn = "9780128211083",

series = "Progress in Brain Research",

publisher = "Elsevier B.V.",

pages = "343--369",

editor = "Shuu-Jiun Wang and Shuu-Jiun Wang and Lau, {Chi Ieong} and Lau, {Chi Ieong} and Lau, {Chi Ieong} and Lau, {Chi Ieong} and Lau, {Chi Ieong}",

booktitle = "Progress in Brain Research",

}

Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine? / Song, Tae Jin; Kim, Byung Su; Chu, Min Kyung.
Progress in Brain Research. ed. / Shuu-Jiun Wang; Shuu-Jiun Wang; Chi Ieong Lau; Chi Ieong Lau; Chi Ieong Lau; Chi Ieong Lau; Chi Ieong Lau. Elsevier B.V., 2020. p. 343-369 (Progress in Brain Research; Vol. 255).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Therapeutic role of melatonin in migraine prophylaxis

T2 - Is there a link between sleep and migraine?

AU - Song, Tae Jin

AU - Kim, Byung Su

AU - Chu, Min Kyung

N1 - Funding Information: TJS and BSK declare that there are no conflicts of interest regarding this submission. MKC is a site investigator for a multi-center trial sponsored by Otsuka Korea, Novartis International AG, and Eli Lilly and Company. He has served as an advisory member for Teva and received lecture honoraria from Allergan Korea, Handok-Teva, and Yuyu Pharmaceutical Company in the past 24 months. He received grants from Yonsei University College of Medicine (2018-32-0037) and National Research Foundation of Korea (2019R1F1A1053841). Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2019R1F1A1053841). Publisher Copyright: © 2020 Elsevier B.V.

PY - 2020

Y1 - 2020

N2 - Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.

AB - Melatonin is a ubiquitously distributed molecule that possesses diverse functions. Melatonin plays a key role in the endogenous circadian rhythms of humans via light stimulation in the hypothalamus. In addition, melatonin has roles in the opioid system, the nitric oxide pathway, free radical scavenging, inflammation, and antinociception. Melatonin is nontoxic and relatively safe. Recently, exogenous melatonin has been shown to have significant effects in the treatment of migraine. Further, it has demonstrated efficacy in the treatment of sleep disorders, including insomnia, circadian rhythm sleep-wake disorders, parasomnias, and sleep breathing disorders. Sleep disorders are commonly reported by those who experience migraine, and migraine and sleep disorders have been reported to be closely associated in cross-sectional studies. Longitudinal studies have shown that some sleep disorders and migraine show bidirectional comorbidities. Therefore, the identification and treatment of sleep disorders is important when treating migraine. Melatonin represents a promising treatment strategy for both disorders, especially when these conditions are combined.

KW - Circadian rhythm

KW - Circadian rhythm sleep disorders

KW - Headache

KW - Insomnia

KW - Melatonin

KW - Migraine

UR - http://www.scopus.com/inward/record.url?scp=85086229548&partnerID=8YFLogxK

U2 - 10.1016/bs.pbr.2020.05.014

DO - 10.1016/bs.pbr.2020.05.014

M3 - Chapter

C2 - 33008513

AN - SCOPUS:85086229548

SN - 9780128211083

T3 - Progress in Brain Research

SP - 343

EP - 369

BT - Progress in Brain Research

A2 - Wang, Shuu-Jiun

A2 - Lau, Chi Ieong

PB - Elsevier B.V.

ER -

Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?

Abstract

Publication series

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this