Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Jin A. Shin; Hyunah Lee; Yoo Kyoung Lim; Yaekyu Koh; Ji Ha Choi; Eun Mi Park

doi:10.1016/j.jneuroim.2010.06.017

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Jin A. Shin, Hyunah Lee, Yoo Kyoung Lim, Yaekyu Koh, Ji Ha Choi, Eun Mi Park

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5. mg/kg for males and 1. mg/kg for females) administered 3. h after ischemic stroke. Administration of resveratrol 6. h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1β and TNF-α, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke.

Original language	English
Pages (from-to)	93-100
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	227
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.06.017
State	Published - Oct 2010

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea ( A080078 ) .

Keywords

Acute ischemic stroke
Microglial activation
Pro-inflammatory cytokines
Reactive oxygen species
Resveratrol
Sex difference

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10.1016/j.jneuroim.2010.06.017

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title = "Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke",

abstract = "We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5. mg/kg for males and 1. mg/kg for females) administered 3. h after ischemic stroke. Administration of resveratrol 6. h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1β and TNF-α, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke.",

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author = "Shin, {Jin A.} and Hyunah Lee and Lim, {Yoo Kyoung} and Yaekyu Koh and Choi, {Ji Ha} and Park, {Eun Mi}",

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AU - Lim, Yoo Kyoung

AU - Koh, Yaekyu

AU - Choi, Ji Ha

AU - Park, Eun Mi

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AB - We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5. mg/kg for males and 1. mg/kg for females) administered 3. h after ischemic stroke. Administration of resveratrol 6. h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1β and TNF-α, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke.

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KW - Microglial activation

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KW - Reactive oxygen species

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Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Abstract

Bibliographical note

Keywords

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