Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke

Jin A. Shin, Hyunah Lee, Yoo Kyoung Lim, Yaekyu Koh, Ji Ha Choi, Eun Mi Park

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5. mg/kg for males and 1. mg/kg for females) administered 3. h after ischemic stroke. Administration of resveratrol 6. h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1β and TNF-α, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalJournal of Neuroimmunology
Volume227
Issue number1-2
DOIs
StatePublished - Oct 2010

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea ( A080078 ) .

Keywords

  • Acute ischemic stroke
  • Microglial activation
  • Pro-inflammatory cytokines
  • Reactive oxygen species
  • Resveratrol
  • Sex difference

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