The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARα-positive acute promyelocytic leukemia: Results of a prospective trial

Seok Lee; Yoo Jin Kim; Ki Seong Eom; Chang Ki Min; Hee Je Kim; Seok Goo Cho; Jong Wook Lee; Woo Sung Min; Chun Choo Kim

The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARα-positive acute promyelocytic leukemia: Results of a prospective trial

Seok Lee, Yoo Jin Kim, Ki Seong Eom, Chang Ki Min, Hee Je Kim, Seok Goo Cho, Jong Wook Lee, Woo Sung Min, Chun Choo Kim

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Seventy adults with acute promyelocytic leukemia were studied to clarify the significance of the level and kinetics of minimal residual disease (MRD) over their entire treatment course by real-time quantitative polymerase chain reaction. At a median follow-up of 44 months, nine relapses had occurred. The 5-year probabilities of relapse and disease-free survival were 17.3±5.4% and 81.5±5.4%, respectively. A MRD level of >10^-3 after first consolidation was the most powerful predictor of relapse (85.7±13.2% versus 7.3±4.1%, p<0.001) and disease-free survival (14.3±13.2% versus 91.2±4.3%, p<0.001). Prospective MRD monitoring may allow us to identify subgroups of patients at high risk of relapse earlier during treatment.

Original language	English
Pages (from-to)	671-674
Number of pages	4
Journal	Haematologica
Volume	91
Issue number	5
State	Published - May 2006

Keywords

Acute promyelocytic leukemia
Minimal residual disease
Real-time quantitative polymerase chain reaction

Cite this

@article{1028502d2c114357b9398926c443e0a5,

title = "The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARα-positive acute promyelocytic leukemia: Results of a prospective trial",

abstract = "Seventy adults with acute promyelocytic leukemia were studied to clarify the significance of the level and kinetics of minimal residual disease (MRD) over their entire treatment course by real-time quantitative polymerase chain reaction. At a median follow-up of 44 months, nine relapses had occurred. The 5-year probabilities of relapse and disease-free survival were 17.3±5.4\% and 81.5±5.4\%, respectively. A MRD level of >10-3 after first consolidation was the most powerful predictor of relapse (85.7±13.2\% versus 7.3±4.1\%, p<0.001) and disease-free survival (14.3±13.2\% versus 91.2±4.3\%, p<0.001). Prospective MRD monitoring may allow us to identify subgroups of patients at high risk of relapse earlier during treatment.",

keywords = "Acute promyelocytic leukemia, Minimal residual disease, Real-time quantitative polymerase chain reaction",

author = "Seok Lee and Kim, \{Yoo Jin\} and Eom, \{Ki Seong\} and Min, \{Chang Ki\} and Kim, \{Hee Je\} and Cho, \{Seok Goo\} and Lee, \{Jong Wook\} and Min, \{Woo Sung\} and Kim, \{Chun Choo\}",

year = "2006",

month = may,

language = "English",

volume = "91",

pages = "671--674",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "5",

}

TY - JOUR

T1 - The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARα-positive acute promyelocytic leukemia

T2 - Results of a prospective trial

AU - Lee, Seok

AU - Kim, Yoo Jin

AU - Eom, Ki Seong

AU - Min, Chang Ki

AU - Kim, Hee Je

AU - Cho, Seok Goo

AU - Lee, Jong Wook

AU - Min, Woo Sung

AU - Kim, Chun Choo

PY - 2006/5

Y1 - 2006/5

N2 - Seventy adults with acute promyelocytic leukemia were studied to clarify the significance of the level and kinetics of minimal residual disease (MRD) over their entire treatment course by real-time quantitative polymerase chain reaction. At a median follow-up of 44 months, nine relapses had occurred. The 5-year probabilities of relapse and disease-free survival were 17.3±5.4% and 81.5±5.4%, respectively. A MRD level of >10-3 after first consolidation was the most powerful predictor of relapse (85.7±13.2% versus 7.3±4.1%, p<0.001) and disease-free survival (14.3±13.2% versus 91.2±4.3%, p<0.001). Prospective MRD monitoring may allow us to identify subgroups of patients at high risk of relapse earlier during treatment.

AB - Seventy adults with acute promyelocytic leukemia were studied to clarify the significance of the level and kinetics of minimal residual disease (MRD) over their entire treatment course by real-time quantitative polymerase chain reaction. At a median follow-up of 44 months, nine relapses had occurred. The 5-year probabilities of relapse and disease-free survival were 17.3±5.4% and 81.5±5.4%, respectively. A MRD level of >10-3 after first consolidation was the most powerful predictor of relapse (85.7±13.2% versus 7.3±4.1%, p<0.001) and disease-free survival (14.3±13.2% versus 91.2±4.3%, p<0.001). Prospective MRD monitoring may allow us to identify subgroups of patients at high risk of relapse earlier during treatment.

KW - Acute promyelocytic leukemia

KW - Minimal residual disease

KW - Real-time quantitative polymerase chain reaction

UR - https://www.scopus.com/pages/publications/33744500987

M3 - Article

C2 - 16627255

AN - SCOPUS:33744500987

SN - 0390-6078

VL - 91

SP - 671

EP - 674

JO - Haematologica

JF - Haematologica

IS - 5

ER -

The significance of minimal residual disease kinetics in adults with newly diagnosed PML-RARα-positive acute promyelocytic leukemia: Results of a prospective trial

Abstract

Keywords

Fingerprint

Cite this