TY - JOUR
T1 - The Selective Function of Quantum Biological Electron Transfer between DNA Bases and Metal Ions in DNA Replication
AU - Zhang, Xianjing
AU - Zhu, Zhi
AU - Liu, Wenpeng
AU - Gao, Feng
AU - Guo, Jun
AU - Song, Bo
AU - Lee, Luke P.
AU - Zhang, Feng
N1 - Publisher Copyright:
© 2022 American Chemical Society.
PY - 2022/8/25
Y1 - 2022/8/25
N2 - Metal ions play vital roles in the electron transfer between biological molecules in humans, animals, and plants. However, the electron transfer between metal ions and nucleic acids and its impact on DNA-ion binding during DNA replication has been ignored. Here, we present a long-range quantum biological electron transfer (QBET) between DNA bases and metal ions and its selective function of DNA-ion binding in DNA replication. We discover biophysical DNA-ion binding and create biological filters that allow selective DNA replication by dual modulators of the valence and concentration of metal ions. QBET-based DNA replication filters provide powerful tools for ultrasensitive polymerase chain reaction (PCR) to selectively amplify target sequences with a discrete concentration window of metal ions; for example, Au3+ exhibits a concentration window that is approximately 3 orders of magnitude lower than that of Na+. DNA-ion filters provide new perspectives into metal ion-mediated QBET in DNA replication and hold great potential in life sciences and medical applications.
AB - Metal ions play vital roles in the electron transfer between biological molecules in humans, animals, and plants. However, the electron transfer between metal ions and nucleic acids and its impact on DNA-ion binding during DNA replication has been ignored. Here, we present a long-range quantum biological electron transfer (QBET) between DNA bases and metal ions and its selective function of DNA-ion binding in DNA replication. We discover biophysical DNA-ion binding and create biological filters that allow selective DNA replication by dual modulators of the valence and concentration of metal ions. QBET-based DNA replication filters provide powerful tools for ultrasensitive polymerase chain reaction (PCR) to selectively amplify target sequences with a discrete concentration window of metal ions; for example, Au3+ exhibits a concentration window that is approximately 3 orders of magnitude lower than that of Na+. DNA-ion filters provide new perspectives into metal ion-mediated QBET in DNA replication and hold great potential in life sciences and medical applications.
UR - http://www.scopus.com/inward/record.url?scp=85136705429&partnerID=8YFLogxK
U2 - 10.1021/acs.jpclett.2c01877
DO - 10.1021/acs.jpclett.2c01877
M3 - Article
C2 - 35969805
AN - SCOPUS:85136705429
SN - 1948-7185
VL - 13
SP - 7779
EP - 7787
JO - Journal of Physical Chemistry Letters
JF - Journal of Physical Chemistry Letters
IS - 33
ER -