The Selective Function of Quantum Biological Electron Transfer between DNA Bases and Metal Ions in DNA Replication

Xianjing Zhang, Zhi Zhu, Wenpeng Liu, Feng Gao, Jun Guo, Bo Song, Luke P. Lee, Feng Zhang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Metal ions play vital roles in the electron transfer between biological molecules in humans, animals, and plants. However, the electron transfer between metal ions and nucleic acids and its impact on DNA-ion binding during DNA replication has been ignored. Here, we present a long-range quantum biological electron transfer (QBET) between DNA bases and metal ions and its selective function of DNA-ion binding in DNA replication. We discover biophysical DNA-ion binding and create biological filters that allow selective DNA replication by dual modulators of the valence and concentration of metal ions. QBET-based DNA replication filters provide powerful tools for ultrasensitive polymerase chain reaction (PCR) to selectively amplify target sequences with a discrete concentration window of metal ions; for example, Au3+ exhibits a concentration window that is approximately 3 orders of magnitude lower than that of Na+. DNA-ion filters provide new perspectives into metal ion-mediated QBET in DNA replication and hold great potential in life sciences and medical applications.

Original languageEnglish
Pages (from-to)7779-7787
Number of pages9
JournalJournal of Physical Chemistry Letters
Volume13
Issue number33
DOIs
StatePublished - 25 Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society.

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