The Rome III classification of dyspepsia: Will it help research?

Nicholas J. Talley, Kevin Ruff, Xuan Jiang, Hye Kyung Jung

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


A major change in the Rome III criteria relates to the condition previously called functional dyspepsia (FD). Rome I and Rome II defined FD as pain or discomfort centered in the upper abdomen without a definite structural or biochemical explanation. The condition was further sub-classified into ulcer-like or dysmotility-like dyspepsia. However, subsequent studies failed to show that single-symptoms are present in the vast majority of patients, and most symptoms failed to correlate with any physiological abnormalities. In Rome III, FD as a broad category was no longer considered useful in terms of research, but rather was defined by two new symptom entities, namely epigastric pain (epigastric pain syndrome) and meal-related symptoms (postprandial distress syndrome). We predict these changes will stimulate new research into the underlying pathophysiological disturbances, as well as impact the diagnosis and treatment of dyspepsia; the classification should advance the field, and we review the challenges ahead.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalDigestive Diseases
Issue number3
StatePublished - May 2008


  • Dyspepsia
  • Functional dyspepsia
  • Functional gastrointestinal disorder
  • Non-ulcer dyspepsia


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