The roles of CD137 signaling in atherosclerosis

In Hyuk Jung, Goo Taeg Oh

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.

Original languageEnglish
Pages (from-to)753-761
Number of pages9
JournalKorean Circulation Journal
Volume46
Issue number6
DOIs
StatePublished - Nov 2016

Keywords

  • Atherosclerosis
  • CD137
  • Plaque stability
  • T cell

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