The Role of Oxidative Stress in Neurodegenerative Diseases

Research output: Contribution to journalReview articlepeer-review

730 Scopus citations

Abstract

Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs especially vulnerable to the effects of ROS because of its high oxygen demand and its abundance of peroxidation-susceptible lipid cells. Previous studies have demonstrated that oxidative stress plays a central role in a common pathophysiology of neurodegenerative diseases such as Alzheimer s disease and Parkinson s disease. Antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases, although the results with regard to their efficacy of treating neurodegenerative disease have been inconsistent. In this review, we will discuss the role of oxidative stress in the pathophysiology of neurodegenerative diseases and in vivo measurement of an index of damage by oxidative stress. Moreover, the present knowledge on antioxidant in the treatment of neurodegenerative diseases and future directions will be outlined.

Original languageEnglish
Pages (from-to)325-340
Number of pages16
JournalExperimental Neurobiology
Volume24
Issue number4
DOIs
StatePublished - 2015

Keywords

  • Alzheimer s disease
  • Antioxidant
  • Neurodegenerative disease
  • Oxidative stress
  • Parkinson s disease
  • Reactive oxygen species

Fingerprint

Dive into the research topics of 'The Role of Oxidative Stress in Neurodegenerative Diseases'. Together they form a unique fingerprint.

Cite this