The role of macrophage lipophagy in reverse cholesterol transport

Se Jin Jeong, Mi Ni Lee, Goo Taeg Oh

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalEndocrinology and Metabolism
Volume32
Issue number1
DOIs
StatePublished - 1 Mar 2017

Keywords

  • Atherosclerosis
  • Cholesterol efflux
  • Lipophagy
  • Macrophages
  • Reverse cholesterol transport

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