Abstract
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 41-46 |
| Number of pages | 6 |
| Journal | Endocrinology and Metabolism |
| Volume | 32 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Mar 2017 |
Bibliographical note
Publisher Copyright:© 2017 Korean Endocrine Society.
Keywords
- Atherosclerosis
- Cholesterol efflux
- Lipophagy
- Macrophages
- Reverse cholesterol transport