The Role of Cerebrovascular Disease in Amyloid Deposition

Young Noh, Sang Won Seo, Seun Jeon, Jong Min Lee, Jae Seung Kim, Jae Hong Lee, Jung Hyun Kim, Geon Ha Kim, Byoung Seok Ye, Hanna Cho, Hee Jin Kim, Cindy W. Yoon, Yearn Seong Choe, Kyung Han Lee, Michael W. Weiner, Duk L. Na

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Some patients clinically diagnosed with subcortical vascular cognitive impairment (SVCI) have co-morbidity with AD pathology. Objective: We investigated topographical differences in amyloid burden between SVCI and Alzheimer's disease type cognitive impairment (ADCI) using [11 C] Pittsburgh compound B (PiB) positron emission tomography (PET). The purpose of this study was to investigate the role of cerebrovascular disease (CVD) in amyloid deposition. Methods: We recruited 44 patients with SVCI and 44 patients with ADCI (amnestic mild cognitive impairment or Alzheimer's disease) with absent or minimal white matter hyperintensities, all with PiB-positive PET scans [PiB+]. As controls, we included 13 participants with normal cognition and PiB-negative scans. We divided the SVCI and ADCI patients into three groups according to global PiB retention ratio of SVCI, and then compared the tertiles in terms of the distribution of PiB retention using statistical parametric mapping analyses. Lobar to global PiB retention ratio and asymmetry indices were also compared between SVCI and ADCI groups Results: Compared to PiB+ ADCI patients, PiB+ SVCI patients exhibited: 1) increased left-right asymmetry, and increased anterior-posterior difference; and 2) increased PiB retention in the parietal cortex, the occipital cortex and the precuneus-posterior cingulate cortex. In contrast, ADCI patients showed increased PiB retention in the striatum. When stratified by level of PiB retention, each group showed different characteristics. Conclusion: Our results showed that the distribution of amyloid deposition differed between patients with PiB+ SVCI and ADCI. These suggest that CVD contribute to and alter the known progression pattern in amyloid deposition in Alzheimer's disease.

Original languageEnglish
Pages (from-to)1015-1026
Number of pages12
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016-IOS Press and the authors. All rights reserved.


  • Alzheimer's disease
  • cerebrovascular disease
  • magnetic resonance imaging
  • positron emission tomography
  • vascular dementia


Dive into the research topics of 'The Role of Cerebrovascular Disease in Amyloid Deposition'. Together they form a unique fingerprint.

Cite this