The risk of preterm birth in vanishing twin: A multicenter prospective cohort study

Ji Su Seong, You Jung Han, Min Hyoung Kim, Jae Yoon Shim, Jae Yoon Shim, Mi Young Lee, Sooyoung Oh, Joon Ho Lee, Soo Hyun Kim, Dong Hyun Cha, Geum Joon Cho, Han Sung Kwon, Byoung Jae Kim, Byoung Jae Kim, Mi Hye Park, Hee Young Cho, Hyun Sun Ko, Chan Wook Park, Joong Shin Park, Jong Kwan JunHyun Mee Ryu, Seung Mi Lee

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9 Scopus citations


Objective To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT). Study design This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery. Results A total of 4,746 women were included in the final analysis, and.The frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception. Conclusion Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.

Original languageEnglish
Article numbere0233097
JournalPLoS ONE
Issue number5 May
StatePublished - May 2020

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© 2020 Seong et al.


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