The risk of preterm birth in vanishing twin: A multicenter prospective cohort study

Ji Su Seong; You Jung Han; Min Hyoung Kim; Jae Yoon Shim; Jae Yoon Shim; Mi Young Lee; Sooyoung Oh; Joon Ho Lee; Soo Hyun Kim; Dong Hyun Cha; Geum Joon Cho; Han Sung Kwon; Byoung Jae Kim; Byoung Jae Kim; Mi Hye Park; Hee Young Cho; Hyun Sun Ko; Chan Wook Park; Joong Shin Park; Jong Kwan Jun; Hyun Mee Ryu; Seung Mi Lee

doi:10.1371/journal.pone.0233097

The risk of preterm birth in vanishing twin: A multicenter prospective cohort study

Ji Su Seong, You Jung Han, Min Hyoung Kim, Jae Yoon Shim, Jae Yoon Shim, Mi Young Lee, Sooyoung Oh, Joon Ho Lee, Soo Hyun Kim, Dong Hyun Cha, Geum Joon Cho, Han Sung Kwon, Byoung Jae Kim, Byoung Jae Kim, Mi Hye Park, Hee Young Cho, Hyun Sun Ko, Chan Wook Park, Joong Shin Park, Jong Kwan JunHyun Mee Ryu, Seung Mi Lee

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT). Study design This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery. Results A total of 4,746 women were included in the final analysis, and.The frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception. Conclusion Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.

Original language	English
Article number	e0233097
Journal	PLoS ONE
Volume	15
Issue number	5 May
DOIs	https://doi.org/10.1371/journal.pone.0233097
State	Published - May 2020

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© 2020 Seong et al.

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Seong, J. S., Han, Y. J., Kim, M. H., Shim, J. Y., Shim, J. Y., Lee, M. Y., Oh, S., Lee, J. H., Kim, S. H., Cha, D. H., Cho, G. J., Kwon, H. S., Kim, B. J., Kim, B. J., Park, M. H., Cho, H. Y., Ko, H. S., Park, C. W., Park, J. S., ... Lee, S. M. (2020). The risk of preterm birth in vanishing twin: A multicenter prospective cohort study. PLoS ONE, 15(5 May), Article e0233097. https://doi.org/10.1371/journal.pone.0233097

@article{610257202eff4f07a2571dbb52c702c2,

title = "The risk of preterm birth in vanishing twin: A multicenter prospective cohort study",

abstract = "Objective To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT). Study design This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery. Results A total of 4,746 women were included in the final analysis, and.The frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception. Conclusion Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.",

author = "Seong, {Ji Su} and Han, {You Jung} and Kim, {Min Hyoung} and Shim, {Jae Yoon} and Shim, {Jae Yoon} and Lee, {Mi Young} and Sooyoung Oh and Lee, {Joon Ho} and Kim, {Soo Hyun} and Cha, {Dong Hyun} and Cho, {Geum Joon} and Kwon, {Han Sung} and Kim, {Byoung Jae} and Kim, {Byoung Jae} and Park, {Mi Hye} and Cho, {Hee Young} and Ko, {Hyun Sun} and Park, {Chan Wook} and Park, {Joong Shin} and Jun, {Jong Kwan} and Ryu, {Hyun Mee} and Lee, {Seung Mi}",

note = "Publisher Copyright: {\textcopyright} 2020 Seong et al.",

year = "2020",

month = may,

doi = "10.1371/journal.pone.0233097",

language = "English",

volume = "15",

journal = "PLoS ONE",

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Seong, JS, Han, YJ, Kim, MH, Shim, JY, Shim, JY, Lee, MY, Oh, S, Lee, JH, Kim, SH, Cha, DH, Cho, GJ, Kwon, HS, Kim, BJ, Kim, BJ, Park, MH, Cho, HY, Ko, HS, Park, CW, Park, JS, Jun, JK, Ryu, HM & Lee, SM 2020, 'The risk of preterm birth in vanishing twin: A multicenter prospective cohort study', PLoS ONE, vol. 15, no. 5 May, e0233097. https://doi.org/10.1371/journal.pone.0233097

TY - JOUR

T1 - The risk of preterm birth in vanishing twin

T2 - A multicenter prospective cohort study

AU - Seong, Ji Su

AU - Han, You Jung

AU - Kim, Min Hyoung

AU - Shim, Jae Yoon

AU - Lee, Mi Young

AU - Oh, Sooyoung

AU - Lee, Joon Ho

AU - Kim, Soo Hyun

AU - Cha, Dong Hyun

AU - Cho, Geum Joon

AU - Kwon, Han Sung

AU - Kim, Byoung Jae

AU - Park, Mi Hye

AU - Cho, Hee Young

AU - Ko, Hyun Sun

AU - Park, Chan Wook

AU - Park, Joong Shin

AU - Jun, Jong Kwan

AU - Ryu, Hyun Mee

AU - Lee, Seung Mi

PY - 2020/5

Y1 - 2020/5

N2 - Objective To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT). Study design This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery. Results A total of 4,746 women were included in the final analysis, and.The frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception. Conclusion Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.

AB - Objective To evaluate not only the risk of total preterm birth (PTB) but also spontaneous preterm birth (sPTB) and indicated preterm birth (iPTB) in vanishing twin (VT). Study design This is a secondary analysis of a multicenter prospective cohort study. In 12 different healthcare institutions, women with singleton pregnancies were enrolled in early pregnancy and followed up till delivery. Results A total of 4,746 women were included in the final analysis, and.The frequency of VT was 1.1% (54/4746). VT group had a higher risk for total PTB (PTB<34 weeks, 2.1% vs. 14.8%, p<0.001; PTB<32 weeks, 1.6% vs. 13.0%, p<0.001; PTB<28 weeks, 0.9% vs. 13.0%, p<0.001) than singleton group. The VT group had increased risk for both sPTB and iPTB (<34 weeks, <32 weeks, and <28 weeks), and this increased risk for sPTB and iPTB in VT group remained significant even after controlling for confounders such as maternal age, parity, pre-pregnancy BMI, and mode of conception. Conclusion Vanishing twin can be an independent risk factor for both sPTB and iPTB when compared with singleton pregnancy.

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U2 - 10.1371/journal.pone.0233097

DO - 10.1371/journal.pone.0233097

M3 - Article

C2 - 32470065

AN - SCOPUS:85085715134

SN - 1932-6203

VL - 15

JO - PLoS ONE

JF - PLoS ONE

IS - 5 May

M1 - e0233097

ER -

The risk of preterm birth in vanishing twin: A multicenter prospective cohort study

Abstract

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