The protective effects of alisol a 24-Acetate from alisma canaliculatum on ovariectomy induced bone loss in vivo

Yun Ho Hwang, Kyung Yun Kang, Sung Ju Lee, Sang Jip Nam, Young Jin Son, Sung Tae Yee

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Alisma canaliculatum is a herb commonly used in traditional Korean medicine, and has been shown in scientific studies to have antitumor, diuretic hepatoprotective, and antibacterial effects. Recently, the anti-osteoclastogenesis of alisol A 24-acetate from Alisma canaliculatum was investigated in vitro. However, the influence of alisol A 24-acetate on osteoporosis in animals has not been investigated. The present study was undertaken to investigate the anti-osteoporotic effect of alisol A 24-acetate on bone mass in ovariectomized (OVX) mice and to identify the mechanism responsible for its effects. OVX mice were treated daily with 0.5 or 2 μg/g of alisol A 24-acetate for a period of six weeks. It was found that these administrations significantly suppressed osteoporosis in OVX mice and improved bone morphometric parameters. The serum estradiol, bone alkaline phosphatase levels, regulatory T/Th17 cell numbers were significantly increased by alisol A 24-acetate as compared with untreated OVX mice. In addition, TRAP activity was inhibited by alisol A 24-acetate in OVX mice. These results suggest alisol A 24-acetate effectively prevents bone loss in OVX mice, and that it can be considered a potential therapeutic for the treatment of postmenopausal osteoporosis.

Original languageEnglish
Article number21010074
JournalMolecules
Volume21
Issue number1
DOIs
StatePublished - 1 Jan 2016

Keywords

  • Alisma canaliculatum
  • Alisol a 24-acetate
  • Bone loss
  • Osteoporosis
  • Regulator t cell
  • Traditional Korean medicine

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