TY - JOUR
T1 - The prognostic implications of cystic change in clear cell renal cell carcinoma
AU - Park, Heae Surng
AU - Jung, Eun Jung
AU - Myung, Jae Kyung
AU - Moon, Kyung Chul
PY - 2010/4
Y1 - 2010/4
N2 - Background: Cystic renal cell carcinoma has been reported to have a good prognosis. However, previous studies included cases of multilocular cystic renal cell carcinoma, which has an excellent prognosis, and renal cell carcinoma with cystic necrosis, which has an adverse prognosis. Therefore, we analyzed the prognostic influence of cystic change in clear cell renal cell carcinoma after excluding those morphological features. Methods: We identified 225 patients with clear cell renal cell carcinoma who underwent nephrectomy between 2001 and 2003. The clinicopathologic features were compared with clinical outcomes. Results: Cystic change in clear cell renal cell carcinoma (n = 66) was significantly associated with younger patient age (< 55), smaller tumor size (≤ 4 cm), lower pT stage (pT1, T2), M0 stage at initial diagnosis, lower tumor, node, and metastasis stage (I, II), and lower nuclear grade (1, 2). Patients with cystic change in clear cell renal cell carcinoma had significantly longer cancer-specific (p = 0.015) and progression-free survival (p = 0.004) than those without cystic change, by univariate analysis. Multivariate analysis revealed that cystic change significantly decreased the risk of cancer progression (risk ratio, 0.27; 95% confidence interval, 0.11 to 0.69). Conclusions: In patients with clear cell renal cell carcinoma, cystic change is a good independent predictor for survival.
AB - Background: Cystic renal cell carcinoma has been reported to have a good prognosis. However, previous studies included cases of multilocular cystic renal cell carcinoma, which has an excellent prognosis, and renal cell carcinoma with cystic necrosis, which has an adverse prognosis. Therefore, we analyzed the prognostic influence of cystic change in clear cell renal cell carcinoma after excluding those morphological features. Methods: We identified 225 patients with clear cell renal cell carcinoma who underwent nephrectomy between 2001 and 2003. The clinicopathologic features were compared with clinical outcomes. Results: Cystic change in clear cell renal cell carcinoma (n = 66) was significantly associated with younger patient age (< 55), smaller tumor size (≤ 4 cm), lower pT stage (pT1, T2), M0 stage at initial diagnosis, lower tumor, node, and metastasis stage (I, II), and lower nuclear grade (1, 2). Patients with cystic change in clear cell renal cell carcinoma had significantly longer cancer-specific (p = 0.015) and progression-free survival (p = 0.004) than those without cystic change, by univariate analysis. Multivariate analysis revealed that cystic change significantly decreased the risk of cancer progression (risk ratio, 0.27; 95% confidence interval, 0.11 to 0.69). Conclusions: In patients with clear cell renal cell carcinoma, cystic change is a good independent predictor for survival.
KW - Carcinoma
KW - Pathology
KW - Prognosis
KW - Renal cell
UR - http://www.scopus.com/inward/record.url?scp=77955034082&partnerID=8YFLogxK
U2 - 10.4132/KoreanJPathol.2010.44.2.149
DO - 10.4132/KoreanJPathol.2010.44.2.149
M3 - Article
AN - SCOPUS:77955034082
SN - 1738-1843
VL - 44
SP - 149
EP - 154
JO - Korean Journal of Pathology
JF - Korean Journal of Pathology
IS - 2
ER -