The mitochondrial genome sequence of Enterobius vermicularis (Nematoda: Oxyurida) - An idiosyncratic gene order and phylogenetic information for chromadorean nematodes

Seokha Kang, Tahera Sultana, Keeseon S. Eom, Yung Chul Park, Nathan Soonthornpong, Steven A. Nadler, Joong Ki Park

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The complete mitochondrial genome sequence was determined for the human pinworm Enterobius vermicularis (Oxyurida: Nematoda) and used to infer its phylogenetic relationship to other major groups of chromadorean nematodes. The E. vermicularis genome is a 14,010-bp circular DNA molecule that encodes 36 genes (12 proteins, 22 tRNAs, and 2 rRNAs). This mtDNA genome lacks atp8, as reported for almost all other nematode species investigated. Phylogenetic analyses (maximum parsimony, maximum likelihood, neighbor joining, and Bayesian inference) of nucleotide sequences for the 12 protein-coding genes of 25 nematode species placed E. vermicularis, a representative of the order Oxyurida, as sister to the main Ascaridida+Rhabditida group. Tree topology comparisons using statistical tests rejected an alternative hypothesis favoring a closer relationship among Ascaridida, Spirurida, and Oxyurida, which has been supported from most studies based on nuclear ribosomal DNA sequences. Unlike the relatively conserved gene arrangement found for most chromadorean taxa, E. vermicularis mtDNA gene order is very unique, not sharing similarity to any other nematode species reported to date. This lack of gene order similarity may represent idiosyncratic gene rearrangements unique to this specific lineage of the oxyurids. To more fully understand the extent of gene rearrangement and its evolutionary significance within the nematode phylogenetic framework, additional mitochondrial genomes representing a greater evolutionary diversity of species must be characterized.

Original languageEnglish
Pages (from-to)87-97
Number of pages11
JournalGene
Volume429
Issue number1-2
DOIs
StatePublished - 15 Jan 2009

Keywords

  • Chromadorea
  • Enterobius vermicularis
  • Gene arrangement
  • Mitochondrial genome
  • Molecular phylogeny
  • Nematoda
  • Oxyurida

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