The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials

So Young Park, Kwang Ha Yoo, Yong Bum Park, Chin Kook Rhee, Jinkyeong Park, Hye Yun Park, Yong Il Hwang, Dong Ah Park, Yun Su Sim

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Abstract

Background: We evaluated the long-term effects of domiciliary noninvasive positive-pressure ventilation (NIPPV) used to treat patients with chronic obstructive pulmonary disease (COPD). Methods: Databases were searched to identify randomized controlled trials of COPD with NIPPV for longer than 1 year. Mortality rates were the primary outcome in this meta-analysis. The eight trials included in this study comprised data from 913 patients. Results: The mortality rates for the NIPPV and control groups were 29% (118/414) and 36% (151/419), suggesting a statistically significant difference (risk ratio [RR], 0.79; 95% confidence interval [CI], 0.65–0.95). Mortality rates were reduced with NIPPV in four trials that included stable COPD patients. There was no difference in admission, acute exacerbation and quality of life between the NIPPV and control groups. There was no significant difference in withdrawal rates between the two groups (RR, 0.99; 95% CI, 0.72–1.36; p=0.94). Conclusion: Maintaining long-term nocturnal NIPPV for more than 1 year, especially in patients with stable COPD, decreased the mortality rate, without increasing the withdrawal rate compared with long-term oxygen treatment.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalTuberculosis and Respiratory Diseases
Volume85
Issue number1
DOIs
StatePublished - Jan 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 The Korean Academy of Tuberculosis and Respiratory Diseases.

Keywords

  • Chronic Obstructive Pulmonary Disease
  • Mortality
  • Noninvasive Positive-Pressure Ventilation

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