The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis

Kang Hoon Je; Ah Reum Han; Hyun Tai Lee; Woongchon Mar; Eun Kyoung Seo

doi:10.1007/BF02980051

The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis

Kang Hoon Je, Ah Reum Han, Hyun Tai Lee, Woongchon Mar, Eun Kyoung Seo

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A sesquiterpene lactone, 1-O-acetyl-4 R,6 S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an IC₅₀ value of 22.1 μM which is more potent than the positive control, L-N⁶-(1-iminoethyl)lysine (IC₅₀ = 33.7 μM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.

Original language	English
Pages (from-to)	83-85
Number of pages	3
Journal	Archives of Pharmacal Research
Volume	27
Issue number	1
DOIs	https://doi.org/10.1007/BF02980051
State	Published - 31 Jan 2004

Bibliographical note

Funding Information:
This investigation was supported by a grant of the Korea Health 21 R&D project, Ministry of Health & Welfare, Republic of Korea (01-PJ2-PG6-01 NA01-0002).

Keywords

1-O-acetyl-4 R,6 S-britannilactone
Compositae
iNOS inhibitor
Inula britannica L. var. chinensis (Rupr.) Reg

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10.1007/BF02980051

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title = "The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis",

abstract = "A sesquiterpene lactone, 1-O-acetyl-4 R,6 S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an IC50 value of 22.1 μM which is more potent than the positive control, L-N6-(1-iminoethyl)lysine (IC50 = 33.7 μM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.",

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author = "Je, {Kang Hoon} and Han, {Ah Reum} and Lee, {Hyun Tai} and Woongchon Mar and Seo, {Eun Kyoung}",

note = "Funding Information: This investigation was supported by a grant of the Korea Health 21 R&D project, Ministry of Health & Welfare, Republic of Korea (01-PJ2-PG6-01 NA01-0002).",

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AU - Lee, Hyun Tai

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AU - Seo, Eun Kyoung

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The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis

Abstract

Bibliographical note

Keywords

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