The impact of total antioxidant capacity on pulmonary function in asthma patients

S. Y. Yoon; T. B. Kim; S. Baek; S. Kim; H. S. Kwon; Y. S. Lee; T. Lee; A. S. Jang; Y. S. Chang; S. H. Cho; B. W. Choi; J. W. Park; D. H. Nham; H. J. Yoon; Y. J. Cho; C. S. Park; H. B. Moon; You Sook Cho

doi:10.5588/ijtld.12.0842

The impact of total antioxidant capacity on pulmonary function in asthma patients

S. Y. Yoon, T. B. Kim, S. Baek, S. Kim, H. S. Kwon, Y. S. Lee, T. Lee, A. S. Jang, Y. S. Chang, S. H. Cho, B. W. Choi, J. W. Park, D. H. Nham, H. J. Yoon, Y. J. Cho, C. S. Park, H. B. Moon, You Sook Cho

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

Original language	English
Pages (from-to)	1544-1550
Number of pages	7
Journal	International Journal of Tuberculosis and Lung Disease
Volume	16
Issue number	11
DOIs	https://doi.org/10.5588/ijtld.12.0842
State	Published - 1 Nov 2012

Keywords

Antioxidants
Asthma
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.12.0842

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Yoon, S. Y., Kim, T. B., Baek, S., Kim, S., Kwon, H. S., Lee, Y. S., Lee, T., Jang, A. S., Chang, Y. S., Cho, S. H., Choi, B. W., Park, J. W., Nham, D. H., Yoon, H. J., Cho, Y. J., Park, C. S., Moon, H. B., & Cho, Y. S. (2012). The impact of total antioxidant capacity on pulmonary function in asthma patients. International Journal of Tuberculosis and Lung Disease, 16(11), 1544-1550. https://doi.org/10.5588/ijtld.12.0842

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title = "The impact of total antioxidant capacity on pulmonary function in asthma patients",

abstract = "BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.",

keywords = "Antioxidants, Asthma, Oxidative stress",

author = "Yoon, {S. Y.} and Kim, {T. B.} and S. Baek and S. Kim and Kwon, {H. S.} and Lee, {Y. S.} and T. Lee and Jang, {A. S.} and Chang, {Y. S.} and Cho, {S. H.} and Choi, {B. W.} and Park, {J. W.} and Nham, {D. H.} and Yoon, {H. J.} and Cho, {Y. J.} and Park, {C. S.} and Moon, {H. B.} and Cho, {You Sook}",

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doi = "10.5588/ijtld.12.0842",

language = "English",

volume = "16",

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Yoon, SY, Kim, TB, Baek, S, Kim, S, Kwon, HS, Lee, YS, Lee, T, Jang, AS, Chang, YS, Cho, SH, Choi, BW, Park, JW, Nham, DH, Yoon, HJ, Cho, YJ, Park, CS, Moon, HB & Cho, YS 2012, 'The impact of total antioxidant capacity on pulmonary function in asthma patients', International Journal of Tuberculosis and Lung Disease, vol. 16, no. 11, pp. 1544-1550. https://doi.org/10.5588/ijtld.12.0842

TY - JOUR

T1 - The impact of total antioxidant capacity on pulmonary function in asthma patients

AU - Yoon, S. Y.

AU - Kim, T. B.

AU - Baek, S.

AU - Kim, S.

AU - Kwon, H. S.

AU - Lee, Y. S.

AU - Lee, T.

AU - Jang, A. S.

AU - Chang, Y. S.

AU - Cho, S. H.

AU - Choi, B. W.

AU - Park, J. W.

AU - Nham, D. H.

AU - Yoon, H. J.

AU - Cho, Y. J.

AU - Park, C. S.

AU - Moon, H. B.

AU - Cho, You Sook

PY - 2012/11/1

Y1 - 2012/11/1

N2 - BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

AB - BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma. OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients. METHOD: A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared. RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1) at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status. CONCLUSION: These results suggest an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.

KW - Antioxidants

KW - Asthma

KW - Oxidative stress

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U2 - 10.5588/ijtld.12.0842

DO - 10.5588/ijtld.12.0842

M3 - Article

C2 - 23044449

AN - SCOPUS:84867220065

SN - 1027-3719

VL - 16

SP - 1544

EP - 1550

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 11

ER -

The impact of total antioxidant capacity on pulmonary function in asthma patients

Abstract

Keywords

UN SDGs

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