The impact of braf mutation on the recurrence of papillary thyroid carcinoma: A meta-analysis

Xin Li, Hyungju Kwon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Previous meta-analyses indicated that the BRAF V600E mutation was associated with an increased recurrence rate of papillary thyroid carcinoma (PTC). However, with recent publications of large cohort studies, the need for an updated meta-analysis increases. Therefore, we conducted a comprehensive meta-analysis to assess the impact of the BRAF V600E mutation on PTC recurrences. We performed a literature search using PubMed, SCOPUS, the Cochrane Database of Systematic Reviews, and the Web of Science Core Collection, from their inception to May 31, 2020. The relevant studies compared recurrence rates using the hazard ratio (HR) of BRAF mutations; 11 studies comprising 4674 patients were identified and included. Recurrence rates in patients with the BRAF V600E mutation were comparable with BRAF wild-type patients (HR 1.16, 95% CI 0.78–1.71), after adjustment for possible confounders. In subgroup analysis, both geographical region (HRs for America, Asia, and Europe were 2.16, 1.31 and 0.66, respectively) and tumor stage (HRs for stage I and II were 1.51 and 4.45, respectively) can affect the HRs of the BRAF mutation for recurrence. In conclusion, the BRAF mutation does not increase the risk of recurrences in patients with PTC. Differences in the geographical region or tumor stage should be considered when interpreting the impact of a BRAF mutation on recurrence.

Original languageEnglish
Article number2056
Pages (from-to)1-10
Number of pages10
JournalCancers
Volume12
Issue number8
DOIs
StatePublished - Aug 2020

Bibliographical note

Funding Information:
Funding: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science and ICT, Republic of Korea (grant number 2017R1C1B5076977).

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science and ICT, Republic of Korea (grant number 2017R1C1B5076977).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • BRAF mutation
  • Papillary thyroid carcinoma
  • Recurrence

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