The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

Keiko Inami; Ikuo Nakanishi; Mine Morita; Miyuki Furukawa; Kei Ohkubo; Shunichi Fukuzumi; Masataka Mochizuki

doi:10.1039/c2ra21928j

The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

Keiko Inami
, Ikuo Nakanishi
, Mine Morita
, Miyuki Furukawa
, Kei Ohkubo
, Shunichi Fukuzumi
, Masataka Mochizuki

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

Original language	English
Pages (from-to)	12714-12717
Number of pages	4
Journal	RSC Advances
Volume	2
Issue number	33
DOIs	https://doi.org/10.1039/c2ra21928j
State	Published - 21 Dec 2012

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title = "The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols",

abstract = "The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.",

author = "Keiko Inami and Ikuo Nakanishi and Mine Morita and Miyuki Furukawa and Kei Ohkubo and Shunichi Fukuzumi and Masataka Mochizuki",

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T1 - The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

AU - Inami, Keiko

AU - Nakanishi, Ikuo

AU - Morita, Mine

AU - Furukawa, Miyuki

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

AU - Mochizuki, Masataka

PY - 2012/12/21

Y1 - 2012/12/21

N2 - The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

AB - The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

UR - https://www.scopus.com/pages/publications/84870051024

U2 - 10.1039/c2ra21928j

DO - 10.1039/c2ra21928j

M3 - Article

AN - SCOPUS:84870051024

SN - 2046-2069

VL - 2

SP - 12714

EP - 12717

JO - RSC Advances

JF - RSC Advances

IS - 33

ER -

The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

Abstract

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