The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

Keiko Inami; Ikuo Nakanishi; Mine Morita; Miyuki Furukawa; Kei Ohkubo; Shunichi Fukuzumi; Masataka Mochizuki

doi:10.1039/c2ra21928j

The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

Keiko Inami, Ikuo Nakanishi, Mine Morita, Miyuki Furukawa, Kei Ohkubo, Shunichi Fukuzumi, Masataka Mochizuki

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

Original language	English
Pages (from-to)	12714-12717
Number of pages	4
Journal	RSC Advances
Volume	2
Issue number	33
DOIs	https://doi.org/10.1039/c2ra21928j
State	Published - 21 Dec 2012

Access to Document

10.1039/c2ra21928j

Cite this

@article{68c48406ab2342df8cbfa7be787c0f26,

title = "The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols",

abstract = "The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.",

author = "Keiko Inami and Ikuo Nakanishi and Mine Morita and Miyuki Furukawa and Kei Ohkubo and Shunichi Fukuzumi and Masataka Mochizuki",

year = "2012",

month = dec,

day = "21",

doi = "10.1039/c2ra21928j",

language = "English",

volume = "2",

pages = "12714--12717",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "33",

}

TY - JOUR

T1 - The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

AU - Inami, Keiko

AU - Nakanishi, Ikuo

AU - Morita, Mine

AU - Furukawa, Miyuki

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

AU - Mochizuki, Masataka

PY - 2012/12/21

Y1 - 2012/12/21

N2 - The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

AB - The hydroxyl radical-scavenging activity of the amino-substituted α-tocopherol analogues was much higher than that of α-tocopherol. Aminochromanoxyl radicals generated from 5- and 7-aminochromanol were successfully detected in aqueous solution at room temperature during ESR measurements. The stability of the aminochromanoxyl radicals leads to a significant enhancement of the radical-scavenging activity.

UR - http://www.scopus.com/inward/record.url?scp=84870051024&partnerID=8YFLogxK

U2 - 10.1039/c2ra21928j

DO - 10.1039/c2ra21928j

M3 - Article

AN - SCOPUS:84870051024

SN - 2046-2069

VL - 2

SP - 12714

EP - 12717

JO - RSC Advances

JF - RSC Advances

IS - 33

ER -

The high stability of intermediate radicals enhances the radical-scavenging activity of aminochromanols

Abstract

Access to Document

Fingerprint

Cite this