The genetic source tracking of human urinary exosomes

Qingfu Zhu, Liming Cheng, Chunyu Deng, Liu Huang, Jiaoyuan Li, Yong Wang, Meng Li, Qinsi Yang, Xianjun Dong, Jianzhong Su, Luke P. Lee, Fei Liu

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.

Original languageEnglish
Article numbere2108876118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number43
DOIs
StatePublished - 26 Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

Keywords

  • Biomarker discovery
  • Cancer diagnosis
  • Exosome origin
  • RNA sequencing

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