The genetic source tracking of human urinary exosomes

Qingfu Zhu; Liming Cheng; Chunyu Deng; Liu Huang; Jiaoyuan Li; Yong Wang; Meng Li; Qinsi Yang; Xianjun Dong; Jianzhong Su; Luke P. Lee; Fei Liu

doi:10.1073/pnas.2108876118

The genetic source tracking of human urinary exosomes

Qingfu Zhu, Liming Cheng, Chunyu Deng, Liu Huang, Jiaoyuan Li, Yong Wang, Meng Li, Qinsi Yang, Xianjun Dong, Jianzhong Su, Luke P. Lee, Fei Liu

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The genetic origins of nanoscale extracellular vesicles in our body fluids remains unclear. Here, we perform a tracking analysis of urinary exosomes via RNA sequencing, revealing that urine exosomes mostly express tissue-specific genes for the bladder and have close cell-genetic relationships to the endothelial cell, basal cell, monocyte, and dendritic cell. Tracking the differentially expressed genes of cancers and corresponding enrichment analysis show urine exosomes are intensively involved in immune activities, indicating that they may be harnessed as reliable biomarkers of noninvasive liquid biopsy in cancer genomic diagnostics and precision medicine.

Original language	English
Article number	e2108876118
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	118
Issue number	43
DOIs	https://doi.org/10.1073/pnas.2108876118
State	Published - 26 Oct 2021

Bibliographical note

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

Keywords

Biomarker discovery
Cancer diagnosis
Exosome origin
RNA sequencing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1073/pnas.2108876118

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AU - Zhu, Qingfu

AU - Cheng, Liming

AU - Deng, Chunyu

AU - Huang, Liu

AU - Li, Jiaoyuan

AU - Wang, Yong

AU - Li, Meng

AU - Yang, Qinsi

AU - Dong, Xianjun

AU - Su, Jianzhong

AU - Lee, Luke P.

AU - Liu, Fei

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KW - Biomarker discovery

KW - Cancer diagnosis

KW - Exosome origin

KW - RNA sequencing

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The genetic source tracking of human urinary exosomes

Abstract

Bibliographical note

Keywords

UN SDGs

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