The fruit of acanthopanax senticosus harms improves arterial stiffness and blood pressure: A randomized, placebo-controlled trial

Eunkyoung Oh, Youjin Kim, Soo Yeon Park, Yeni Lim, Ji Yoon Shin, Ji Yeon Kim, Ji Hyun Kim, Moo Yong Rhee, Oran Kwon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


BACKGROUND/OBJECTIVES: Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while Acanthopanax senticosus Harms (ASH) is a traditional medicinal plant that can improve cardiovascular health. This study aimed to investigate the efficacy of the fruit of ASH on vascular function in apparently healthy subjects. SUBJECTS/METHODS: A 12-week, randomized, double-blind, placebo-controlled design, consisting of healthy adults with at least 2 of the following 3 conditions: borderline high blood pressure (BP; 120 mmHg ≤ systolic BP ≤ 160 mmHg or 80 mmHg ≤ diastolic BP ≤ 100 mmHg), smoking (≥10 cigarettes/day), and borderline blood lipid levels (220 ≤ total cholesterol ≤ 240, 130 ≤ low density lipoprotein cholesterol ≤ 165, or 150 ≤ triglyceride ≤ 220 mg/dL). Randomly assigned 76 subjects who received a placebo or 2 doses of ASH fruit (low, 500 mg/day; high, 1,000 mg/day) completed the intervention. Brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation, carotid intima-media thickness, and BP were measured both at baseline and following the 12-week intervention. Endothelial nitric oxide synthase (eNOS) phosphorylation was assessed by western blotting. RESULTS: Compared with the placebo group, the low-dose group showed more significant changes after the 12-week intervention period in terms of systolic BP (0.1 vs. −7.7 mmHg; P = 0.044), baPWV (31.3 vs. −98.7 cm/s; P = 0.007), and the ratio of phospho-eNOS/eNOS (0.8 vs. 1.22; P = 0.037). CONCLUSIONS: These results suggest that ASH fruit extract at 500 mg/day has the potential to improve BP and arterial stiffness via endothelial eNOS activation in healthy adults with smoking and the tendency of having elevated BP or blood lipid parameters.

Original languageEnglish
Pages (from-to)322-333
Number of pages12
JournalNutrition Research and Practice
Issue number4
StatePublished - Aug 2020

Bibliographical note

Funding Information:
This work was supported by the Forest Science & Technology Project (project No. S111112L010120) and by the Ministry of Science & ICT (NRF2012M3A9C4048761). The funders had no role in study design; the collection, analysis and/or interpretation of data; decision to publish; or preparation of the manuscript.

Publisher Copyright:
© 2020 The Korean Nutrition Society and the Korean Society of Community Nutrition.


  • Acanthopanax
  • Cardiovascular diseases
  • Endothelial nitric oxide synthase
  • Pulse wave velocity
  • Vascular stiffness


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