The first non-enzymatic reduction of acetaldehyde and analogues by an NADH model compound

Masashi Ishikawa, Shunichi Fukuzumi

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

An acid-stable NADH model compound, 9,10-dihydro-10-methylacridine (AcrH2) efficiently reduces acetaldehyde and analogues in the presence of HClO4 in acetonitrile to yield 10-methylacridinium ion and the corresponding alcohols; rates of the acid-catalysed reduction of various aliphatic aldehydes and ketones by AcrH2, which have small primary kinetic isotope effects (kH/kD < 2.0), are well correlated with those of the acid-catalysed electron transfer from the excited state of [Ru(bpy)3]2+ (bpy = 2,2′-bipyridine) to the same substrates.

Original languageEnglish
Pages (from-to)1353-1355
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number19
DOIs
StatePublished - 1990

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