The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

Yu Sung Chun; Ki Kon Lee; Young Ok Ko; Hyunik Shin; Sang Gi Lee

doi:10.1039/b813369g

The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

Yu Sung Chun
, Ki Kon Lee
, Young Ok Ko
, Hyunik Shin
, Sang Gi Lee

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

Original language	English
Pages (from-to)	5098-5100
Number of pages	3
Journal	Chemical Communications
Issue number	41
DOIs	https://doi.org/10.1039/b813369g
State	Published - 2008

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title = "The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles",

abstract = "The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T2 - A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

AU - Sung Chun, Yu

AU - Kon Lee, Ki

AU - Ok Ko, Young

AU - Shin, Hyunik

AU - Lee, Sang Gi

PY - 2008

Y1 - 2008

N2 - The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

AB - The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

UR - https://www.scopus.com/pages/publications/55049131166

U2 - 10.1039/b813369g

DO - 10.1039/b813369g

M3 - Article

C2 - 18956034

AN - SCOPUS:55049131166

SN - 1359-7345

SP - 5098

EP - 5100

JO - Chemical Communications

JF - Chemical Communications

IS - 41

ER -

The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

Abstract

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