The first chemoselective tandem acylation of the Blaise reaction intermediate: A novel method for the synthesis of α-acyl-β-enamino esters, key intermediate for pyrazoles

Yu Sung Chun, Ki Kon Lee, Young Ok Ko, Hyunik Shin, Sang Gi Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The Blaise reaction intermediate, a zinc bromide complex of β-enamino ester, could be activated in situ by addition of a stoichiometric or catalytic amount of n-BuLi to allow chemoselective tandem C2-acylation providing α-acyl-β-enamino esters, which are valuable intermediates for the syntheses of tri- and tetrasubstituted pyrazoles.

Original languageEnglish
Pages (from-to)5098-5100
Number of pages3
JournalChemical Communications
Issue number41
DOIs
StatePublished - 2008

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