The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer

Jeongshin An, Hyungju Kwon, Young Ju Kim

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The gut microbiome can reflect the health condition of the entire body. Firmicutes and Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which are also risk factors for breast cancer. Therefore, the Firmicutes/Bacteroidetes (F/B) ratio was analyzed in patients with breast cancer. Bacterial extracellular vesicles were extracted from the serum of patients with breast cancer and healthy controls. Phyla Firmicutes and Bacteroidetes were analyzed using microbiome sequencing. Prognostic factors for breast cancer and serological test results were analyzed for correlations with the F/B ratio. The F/B ratio was three times lower in patients with breast cancer than in healthy controls. In addition, the risk factor for breast cancer, such as fasting serum glucose, was found to be related to the F/B ratio. The F/B ratio can be used as a risk factor of breast cancer and as a clue to explain underlying mechanisms affecting the development of breast cancer.

Original languageEnglish
Article number2216
JournalJournal of Clinical Medicine
Issue number6
StatePublished - Mar 2023

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C1014094).

Publisher Copyright:
© 2023 by the authors.


  • breast cancer
  • Firmicutes/Bacteroides ratio
  • microbiome


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