The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma

Sung Ae Jung; Suk Kyun Yang; Jeong Sun Kim; Ki Nam Shim; Seock Ah Im; Seung Jae Myung; Hwoon Yong Jung; Chang Sik Yu; Jin Cheon Kim; Weon Seon Hong; Jin Ho Kim; Young Il Min

The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma

Sung Ae Jung, Suk Kyun Yang, Jeong Sun Kim, Ki Nam Shim, Seock Ah Im, Seung Jae Myung, Hwoon Yong Jung, Chang Sik Yu, Jin Cheon Kim, Weon Seon Hong, Jin Ho Kim, Young Il Min

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

BACKGROUND/AIMS: Lymph node (LN) metastasis occurs in approximately 10% of patients with submucosally invasive colorectal carcinoma. This study was performed to determine the role of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) production and microvessel formation on the LN metastasis in submucosally invasive colorectal carcinoma. METHODS: A total of forty-one subjects with surgically resected submucosally invasive colorectal carcinoma were included in this study. Immunohistochemical staining of MMP-2, MMP-9, TIMP-1, TIMP-2, and urokinase-type plasminogen activator were performed. Angiogenesis was evaluated by counting the number of microvessels in each pathologic specimen as identified by CD34 immunohistochemical staining. RESULTS: The depth of submucosal invasion was not significantly correlated with the expression of MMP-2, MMP-9, TIMP-1, TIMP-2, or urokinase-type plasminogen activator, but the microvessel count was significantly correlated with the absolute depth of invasion (r=0.312, p<0.05). Upregulation of TIMP-2 was positively correlated with adjacent lymphatic invasion (p<0.05) and increased TIMP-2 expression was correlated with LN metastasis in submucosally invasive colorectal carcinoma (p=0.088). CONCLUSIONS: These results suggest that the expression of TIMP-2 and the microvessel count may be useful parameters for considering additional surgery after endoscopic treatment of submucosally invasive colorectal carcinoma.

Original language	English
Pages (from-to)	401-408
Number of pages	8
Journal	The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume	45
Issue number	6
State	Published - Jun 2005

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Jung, S. A., Yang, S. K., Kim, J. S., Shim, K. N., Im, S. A., Myung, S. J., Jung, H. Y., Yu, C. S., Kim, J. C., Hong, W. S., Kim, J. H., & Min, Y. I. (2005). The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 45(6), 401-408.

Jung, Sung Ae ; Yang, Suk Kyun ; Kim, Jeong Sun et al. / The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2005 ; Vol. 45, No. 6. pp. 401-408.

@article{1a8fad0669074872911a18943d90ee6b,

title = "The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma",

abstract = "BACKGROUND/AIMS: Lymph node (LN) metastasis occurs in approximately 10% of patients with submucosally invasive colorectal carcinoma. This study was performed to determine the role of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) production and microvessel formation on the LN metastasis in submucosally invasive colorectal carcinoma. METHODS: A total of forty-one subjects with surgically resected submucosally invasive colorectal carcinoma were included in this study. Immunohistochemical staining of MMP-2, MMP-9, TIMP-1, TIMP-2, and urokinase-type plasminogen activator were performed. Angiogenesis was evaluated by counting the number of microvessels in each pathologic specimen as identified by CD34 immunohistochemical staining. RESULTS: The depth of submucosal invasion was not significantly correlated with the expression of MMP-2, MMP-9, TIMP-1, TIMP-2, or urokinase-type plasminogen activator, but the microvessel count was significantly correlated with the absolute depth of invasion (r=0.312, p<0.05). Upregulation of TIMP-2 was positively correlated with adjacent lymphatic invasion (p<0.05) and increased TIMP-2 expression was correlated with LN metastasis in submucosally invasive colorectal carcinoma (p=0.088). CONCLUSIONS: These results suggest that the expression of TIMP-2 and the microvessel count may be useful parameters for considering additional surgery after endoscopic treatment of submucosally invasive colorectal carcinoma.",

author = "Jung, {Sung Ae} and Yang, {Suk Kyun} and Kim, {Jeong Sun} and Shim, {Ki Nam} and Im, {Seock Ah} and Myung, {Seung Jae} and Jung, {Hwoon Yong} and Yu, {Chang Sik} and Kim, {Jin Cheon} and Hong, {Weon Seon} and Kim, {Jin Ho} and Min, {Young Il}",

year = "2005",

month = jun,

language = "English",

volume = "45",

pages = "401--408",

journal = "The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi",

issn = "1598-9992",

publisher = "Korean Society of Gastroenterology",

number = "6",

}

Jung, SA, Yang, SK, Kim, JS, Shim, KN, Im, SA, Myung, SJ, Jung, HY, Yu, CS, Kim, JC, Hong, WS, Kim, JH & Min, YI 2005, 'The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma', The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, vol. 45, no. 6, pp. 401-408.

The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. / Jung, Sung Ae; Yang, Suk Kyun; Kim, Jeong Sun et al.
In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 45, No. 6, 06.2005, p. 401-408.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma

AU - Jung, Sung Ae

AU - Yang, Suk Kyun

AU - Kim, Jeong Sun

AU - Shim, Ki Nam

AU - Im, Seock Ah

AU - Myung, Seung Jae

AU - Jung, Hwoon Yong

AU - Yu, Chang Sik

AU - Kim, Jin Cheon

AU - Hong, Weon Seon

AU - Kim, Jin Ho

AU - Min, Young Il

PY - 2005/6

Y1 - 2005/6

N2 - BACKGROUND/AIMS: Lymph node (LN) metastasis occurs in approximately 10% of patients with submucosally invasive colorectal carcinoma. This study was performed to determine the role of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) production and microvessel formation on the LN metastasis in submucosally invasive colorectal carcinoma. METHODS: A total of forty-one subjects with surgically resected submucosally invasive colorectal carcinoma were included in this study. Immunohistochemical staining of MMP-2, MMP-9, TIMP-1, TIMP-2, and urokinase-type plasminogen activator were performed. Angiogenesis was evaluated by counting the number of microvessels in each pathologic specimen as identified by CD34 immunohistochemical staining. RESULTS: The depth of submucosal invasion was not significantly correlated with the expression of MMP-2, MMP-9, TIMP-1, TIMP-2, or urokinase-type plasminogen activator, but the microvessel count was significantly correlated with the absolute depth of invasion (r=0.312, p<0.05). Upregulation of TIMP-2 was positively correlated with adjacent lymphatic invasion (p<0.05) and increased TIMP-2 expression was correlated with LN metastasis in submucosally invasive colorectal carcinoma (p=0.088). CONCLUSIONS: These results suggest that the expression of TIMP-2 and the microvessel count may be useful parameters for considering additional surgery after endoscopic treatment of submucosally invasive colorectal carcinoma.

AB - BACKGROUND/AIMS: Lymph node (LN) metastasis occurs in approximately 10% of patients with submucosally invasive colorectal carcinoma. This study was performed to determine the role of matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs) production and microvessel formation on the LN metastasis in submucosally invasive colorectal carcinoma. METHODS: A total of forty-one subjects with surgically resected submucosally invasive colorectal carcinoma were included in this study. Immunohistochemical staining of MMP-2, MMP-9, TIMP-1, TIMP-2, and urokinase-type plasminogen activator were performed. Angiogenesis was evaluated by counting the number of microvessels in each pathologic specimen as identified by CD34 immunohistochemical staining. RESULTS: The depth of submucosal invasion was not significantly correlated with the expression of MMP-2, MMP-9, TIMP-1, TIMP-2, or urokinase-type plasminogen activator, but the microvessel count was significantly correlated with the absolute depth of invasion (r=0.312, p<0.05). Upregulation of TIMP-2 was positively correlated with adjacent lymphatic invasion (p<0.05) and increased TIMP-2 expression was correlated with LN metastasis in submucosally invasive colorectal carcinoma (p=0.088). CONCLUSIONS: These results suggest that the expression of TIMP-2 and the microvessel count may be useful parameters for considering additional surgery after endoscopic treatment of submucosally invasive colorectal carcinoma.

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M3 - Article

C2 - 15973074

AN - SCOPUS:33748755463

SN - 1598-9992

VL - 45

SP - 401

EP - 408

JO - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

JF - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

IS - 6

ER -

Jung SA, Yang SK, Kim JS, Shim KN, Im SA, Myung SJ et al. The expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs) and angiogenesis in relation to the depth of tumor invasion and lymph node metastasis in submucosally invasive colorectal carcinoma. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2005 Jun;45(6):401-408.