The essential role of TAZ in normal tissue homeostasis

Mi Gyeong Jeong, Hyo Kyeong Kim, Eun Sook Hwang

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Transcriptional coactivator with PDZ-binding motif (TAZ) has been extensively characterized in organ development, tissue regeneration, and tumor progression. In particular, TAZ functions as a Hippo mediator that regulates organ size, tumor growth and migration. It is highly expressed in various types of human cancer, and has been reported to be associated with tumor metastasis and poor outcomes in cancer patients, suggesting that TAZ is an oncogenic regulator. Yes-associated protein (YAP) has 60% similarity in amino acid sequence to TAZ and plays redundant roles with TAZ in the regulation of cell proliferation and migration of cancer cells. Therefore, TAZ and YAP, which are encoded by paralogous genes, are referred to as TAZ/YAP and are suggested to be functionally equivalent. Despite its similarity to YAP, TAZ can be clearly distinguished from YAP based on its genetic, structural, and functional aspects. In addition, targeting superabundant TAZ can be a promising therapeutic strategy for cancer treatment; however, persistent TAZ inactivation may cause failure of tissue homeostatic control. This review focuses primarily on TAZ, not YAP, discusses its structural features and physiological functions in the regulation of tissue homeostasis, and provides new insights into the drug development targeting TAZ to control reproductive and musculoskeletal disorders.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalArchives of Pharmacal Research
Volume44
Issue number3
DOIs
StatePublished - Mar 2021

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation (2018R1A5A2025286 and 2020R1A2C2004679) funded by the Ministry of Education, Science, and Technology.

Publisher Copyright:
© 2021, The Author(s).

Keywords

  • Hippo pathway
  • TAZ
  • Tissue homeostasis
  • Transcriptional control
  • YAP

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