The essential role of a ZnII Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged CuII-ZnII model of superoxide dismutase

Hideki Ohtsu; Shunichi Fukuzumi

doi:10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L

The essential role of a Zn^II Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged Cu^II-Zn^II model of superoxide dismutase

Hideki Ohtsu, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Reduction and oxidation of semiquinone radicals Q̇^- are facilitated by the Zn^II center of the imidazolate-bridged heterodinuclear Cu^II - Zn^II complex [CuZn(bdpi)(CH₃CN)₂](ClO₄)₃· 2CH₃CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of Q̇^- involves coordiantion of Q̇^- to the Zn^II center of 1; no disproportionation of Q̇^- occurs with the Cu^II-Cu^II analogue of 1. These studies provide mechanistic insight into the role of the Zn^II ion in copper-zinc superoxide dismutase.

Original language	English
Pages (from-to)	4537-4539
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	24
DOIs	https://doi.org/10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L
State	Published - 15 Dec 2000

Keywords

Bioinorganic chemistry
Copper
Radical anions
Zinc

Access to Document

10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L

Cite this

@article{f9b078b29c87456c814fb5dadc3529d2,

title = "The essential role of a ZnII Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged CuII-ZnII model of superoxide dismutase",

abstract = "Reduction and oxidation of semiquinone radicals {\.Q}- are facilitated by the ZnII center of the imidazolate-bridged heterodinuclear CuII - ZnII complex [CuZn(bdpi)(CH3CN)2](ClO4)3 · 2CH3CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of {\.Q}- involves coordiantion of {\.Q}- to the ZnII center of 1; no disproportionation of {\.Q}- occurs with the CuII-CuII analogue of 1. These studies provide mechanistic insight into the role of the ZnII ion in copper-zinc superoxide dismutase.",

keywords = "Bioinorganic chemistry, Copper, Radical anions, Zinc",

author = "Hideki Ohtsu and Shunichi Fukuzumi",

year = "2000",

month = dec,

day = "15",

doi = "10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L",

language = "English",

volume = "39",

pages = "4537--4539",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "24",

}

TY - JOUR

T1 - The essential role of a ZnII Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged CuII-ZnII model of superoxide dismutase

AU - Ohtsu, Hideki

AU - Fukuzumi, Shunichi

PY - 2000/12/15

Y1 - 2000/12/15

N2 - Reduction and oxidation of semiquinone radicals Q̇- are facilitated by the ZnII center of the imidazolate-bridged heterodinuclear CuII - ZnII complex [CuZn(bdpi)(CH3CN)2](ClO4)3 · 2CH3CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of Q̇- involves coordiantion of Q̇- to the ZnII center of 1; no disproportionation of Q̇- occurs with the CuII-CuII analogue of 1. These studies provide mechanistic insight into the role of the ZnII ion in copper-zinc superoxide dismutase.

AB - Reduction and oxidation of semiquinone radicals Q̇- are facilitated by the ZnII center of the imidazolate-bridged heterodinuclear CuII - ZnII complex [CuZn(bdpi)(CH3CN)2](ClO4)3 · 2CH3CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of Q̇- involves coordiantion of Q̇- to the ZnII center of 1; no disproportionation of Q̇- occurs with the CuII-CuII analogue of 1. These studies provide mechanistic insight into the role of the ZnII ion in copper-zinc superoxide dismutase.

KW - Bioinorganic chemistry

KW - Copper

KW - Radical anions

KW - Zinc

UR - https://www.scopus.com/pages/publications/0034671518

U2 - 10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L

DO - 10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L

M3 - Article

AN - SCOPUS:0034671518

SN - 1433-7851

VL - 39

SP - 4537

EP - 4539

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24