The essential role of a ZnII Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged CuII-ZnII model of superoxide dismutase

Hideki Ohtsu; Shunichi Fukuzumi

doi:10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L

The essential role of a Zn^II Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged Cu^II-Zn^II model of superoxide dismutase

Hideki Ohtsu, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Reduction and oxidation of semiquinone radicals Q̇^- are facilitated by the Zn^II center of the imidazolate-bridged heterodinuclear Cu^II - Zn^II complex [CuZn(bdpi)(CH₃CN)₂](ClO₄)₃· 2CH₃CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of Q̇^- involves coordiantion of Q̇^- to the Zn^II center of 1; no disproportionation of Q̇^- occurs with the Cu^II-Cu^II analogue of 1. These studies provide mechanistic insight into the role of the Zn^II ion in copper-zinc superoxide dismutase.

Original language	English
Pages (from-to)	4537-4539
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	24
DOIs	https://doi.org/10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L
State	Published - 15 Dec 2000

Keywords

Bioinorganic chemistry
Copper
Radical anions
Zinc

Access to Document

10.1002/1521-3773(20001215)39:24<4537::AID-ANIE4537>3.0.CO;2-L

Cite this

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title = "The essential role of a ZnII Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged CuII-ZnII model of superoxide dismutase",

abstract = "Reduction and oxidation of semiquinone radicals {\.Q}- are facilitated by the ZnII center of the imidazolate-bridged heterodinuclear CuII - ZnII complex [CuZn(bdpi)(CH3CN)2](ClO4)3 · 2CH3CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of {\.Q}- involves coordiantion of {\.Q}- to the ZnII center of 1; no disproportionation of {\.Q}- occurs with the CuII-CuII analogue of 1. These studies provide mechanistic insight into the role of the ZnII ion in copper-zinc superoxide dismutase.",

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author = "Hideki Ohtsu and Shunichi Fukuzumi",

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T1 - The essential role of a ZnII Ion in the disproportionation of semiquinone radical anion by an imidazolate-bridged CuII-ZnII model of superoxide dismutase

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AU - Fukuzumi, Shunichi

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Y1 - 2000/12/15

N2 - Reduction and oxidation of semiquinone radicals Q̇- are facilitated by the ZnII center of the imidazolate-bridged heterodinuclear CuII - ZnII complex [CuZn(bdpi)(CH3CN)2](ClO4)3 · 2CH3CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of Q̇- involves coordiantion of Q̇- to the ZnII center of 1; no disproportionation of Q̇- occurs with the CuII-CuII analogue of 1. These studies provide mechanistic insight into the role of the ZnII ion in copper-zinc superoxide dismutase.

AB - Reduction and oxidation of semiquinone radicals Q̇- are facilitated by the ZnII center of the imidazolate-bridged heterodinuclear CuII - ZnII complex [CuZn(bdpi)(CH3CN)2](ClO4)3 · 2CH3CN (1; see picture for formula of bdpi). The stoichiometric disproportionation of Q̇- involves coordiantion of Q̇- to the ZnII center of 1; no disproportionation of Q̇- occurs with the CuII-CuII analogue of 1. These studies provide mechanistic insight into the role of the ZnII ion in copper-zinc superoxide dismutase.

KW - Bioinorganic chemistry

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KW - Radical anions

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