The effects of type 1 diabetes on cerebral white matter

K. Weinger, A. M. Jacobson, G. Musen, I. K. Lyoo, C. M. Ryan, D. C. Jimerson, P. F. Renshaw

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Aim/hypothesis: Studies investigating the structure, neurophysiology and functional outcomes of white matter among type 1 diabetes patients have given conflicting results. Our aim was to investigate the relationship between type 1 diabetes and white matter hyperintensities. Method: We assessed white matter integrity (using magnetic resonance imaging), depressive symptoms and neuropsychological function in 114 type 1 diabetes patients and 58 age-matched non-diabetic controls. Results: Only Fazekas grade 1 and 2 white matter hyperintensities were found among 114 long-duration, relatively young diabetes patients; the severity of lesions did not differ substantially from 58 healthy controls. White matter hyperintensities were not associated with depressive history or with clinical characteristics of diabetes, including retinopathy, severe hypoglycaemia or glycaemia control. Conclusions/interpretation: Our data do not support an association between diabetes characteristics and white matter hyperintensities among relatively young type 1 diabetes participants.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
Issue number3
StatePublished - Mar 2008

Bibliographical note

Funding Information:
Acknowledgements This research was supported by NIDDK R01060754 (A. M. Jacobson), the Herbert Graetz Fund, and in part by the Diabetes and Endocrinology Research Core NIH P30 DK36836, and in part by grant RR 01032 to the Beth Israel Deaconess Medical Center General Clinical Research Center. We thank C. Sparks and A. Burwood for their invaluable assistance in participant recruitment and study organisation.


  • Brain structure
  • Cognition
  • MRI
  • Neuroimaging
  • Type 1 diabetes
  • White matter hyperintensities


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