Abstract
The effects of terpenes on the release and permeation of ofloxacin and lidocaine from moisture-activated composite patches were investigated. Ofloxacin without enhancers showed very low permeation rate (0.58 μg/cm2/hr), and the addition of cineole enhanced the permeation flux 14.1-times; /-menthol and d-limonene increased it 4.7- and 3.5-times, respectively. The highest permeation flux (77.7 ± 25.3 μg/cm2/hr) of lidocaine from the composite patches was also achieved when cineole at the concentration of 0.33% in the gel base was added. /-Menthol also revealed enhancing effect on the permeation of lidocaine; however, d-limonene failed to increase the permeation rate of lidocaine. In conclusion, for effective moisture- activated patches containing lidocaine and ofloxacin, cineole could be used as an effective and safe enhancer.
| Original language | English |
|---|---|
| Pages (from-to) | 75-81 |
| Number of pages | 7 |
| Journal | Drug Delivery |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2009 |
Keywords
- Lidocaine
- Moisture-activated patches
- Ofloxacin
- Terpenes
Fingerprint
Dive into the research topics of 'The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver