TY - JOUR
T1 - The effect of small or diminutive adenomas at baseline colonoscopy on the risk of developing metachronous advanced colorectal neoplasia
T2 - KASID multicenter study
AU - Moon, Chang Mo
AU - Jung, Sung Ae
AU - Eun, Chang Soo
AU - Park, Jae Jun
AU - Seo, Geom Seog
AU - Cha, Jae Myung
AU - Park, Sung Chul
AU - Chun, Jaeyoung
AU - Lee, Hyun Jung
AU - Jung, Yunho
AU - Boo, Sun Jin
AU - Kim, Jin Oh
AU - Joo, Young Eun
AU - Park, Dong Il
N1 - Publisher Copyright:
© 2018 Editrice Gastroenterologica Italiana S.r.l.
PY - 2018/8
Y1 - 2018/8
N2 - Background: The clinical significance of diminutive or small adenomas remains ill defined. Aims: We evaluated the clinical impact of diminutive or small adenomas at baseline on the risk of developing metachronous advanced colorectal neoplasia (CRN). Methods: This multicenter, retrospective cohort study included 2252 patients with 1 or more colorectal adenomas at baseline and subsequent follow-up colonoscopy. Baseline colonoscopy findings were classified into 5 groups: 1 or 2 tubular adenomas (TAs) (<10 mm); 3–10 diminutive TAs (≤5 mm); 3–10 TAs, including 1 or 2 small adenomas (6–10 mm); 3–10 TAs, including 3 or more small adenomas; and advanced adenoma. Results: In multivariate analysis, after adjusting for possible confounding variables (age at baseline, sex, body mass index, smoking habits, family history of colorectal cancer, regular use of aspirin or NSAIDs, and adenoma location), 3–10 TAs including 3 or more small adenomas (hazard ratio [HR] = 2.36, p = 0.034) and advanced adenoma (HR = 2.14, p < 0.001) were independent predictors for the risk of developing metachronous advanced CRN. However, 3–10 diminutive TAs or 3–10 TAs, including 1 or 2 small adenomas, were not associated with this outcome. Conclusions: Multiplicity of diminutive TAs, without advanced lesions, showed no clinical significance for risk of developing metachronous advanced CRN.
AB - Background: The clinical significance of diminutive or small adenomas remains ill defined. Aims: We evaluated the clinical impact of diminutive or small adenomas at baseline on the risk of developing metachronous advanced colorectal neoplasia (CRN). Methods: This multicenter, retrospective cohort study included 2252 patients with 1 or more colorectal adenomas at baseline and subsequent follow-up colonoscopy. Baseline colonoscopy findings were classified into 5 groups: 1 or 2 tubular adenomas (TAs) (<10 mm); 3–10 diminutive TAs (≤5 mm); 3–10 TAs, including 1 or 2 small adenomas (6–10 mm); 3–10 TAs, including 3 or more small adenomas; and advanced adenoma. Results: In multivariate analysis, after adjusting for possible confounding variables (age at baseline, sex, body mass index, smoking habits, family history of colorectal cancer, regular use of aspirin or NSAIDs, and adenoma location), 3–10 TAs including 3 or more small adenomas (hazard ratio [HR] = 2.36, p = 0.034) and advanced adenoma (HR = 2.14, p < 0.001) were independent predictors for the risk of developing metachronous advanced CRN. However, 3–10 diminutive TAs or 3–10 TAs, including 1 or 2 small adenomas, were not associated with this outcome. Conclusions: Multiplicity of diminutive TAs, without advanced lesions, showed no clinical significance for risk of developing metachronous advanced CRN.
KW - Diminutive adenoma
KW - Metachronous colorectal neoplasia
KW - Small adenoma
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85046782652&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2018.04.001
DO - 10.1016/j.dld.2018.04.001
M3 - Article
C2 - 29730157
AN - SCOPUS:85046782652
SN - 1590-8658
VL - 50
SP - 847
EP - 852
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 8
ER -